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Cell Systems
The regulation of genes can be mathematically described by input-output functions that are typically assumed to be time invariant. This fundamental assumption underpins the design of synthetic gene circuits and the quantitative understanding of natural ...
Yihan Lin
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The regulation of genes can be mathematically described by input-output functions that are typically assumed to be time invariant. This fundamental assumption underpins the design of synthetic gene circuits and the quantitative understanding of natural ...
Yihan Lin
exaly +2 more sources
Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory [PDF]
Molecular Cell, 2020 Transcriptional memory of gene expression enables adaptation to repeated stimuli across many organisms. However, the regulation and heritability of transcriptional memory in single cells and through divisions remains poorly understood.
Robert Schneider +2 more
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The yin yang of transcriptional memory
Nature Structural & Molecular BiologyAlejandra Laguillo-Diego, E. Apostolou
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Plant transcriptional memory and associated mechanism of abiotic stress tolerance.
Plant physiology and biochemistry : PPB, 2023Plants face various adverse environmental conditions, particularly with the ongoing changes in global climate, which drastically affect the growth, development and productivity of crops. To cope with these stresses, plants have evolved complex mechanisms,
Ding-Ding Zuo, G. Ahammed, D. Guo
semanticscholar +1 more source
Persistent Transcriptional Programmes Are Associated With Remote Memory
Nature, 2020 The role of gene expression during learning and in short-term memories has been studied extensively(1–3), but less is known about remote memories, which can persist for a lifetime(4).
Stephen Quake +2 more
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Mechanisms of transcriptional memory
Nature Reviews Molecular Cell Biology, 2001How can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development.
N J, Francis, R E, Kingston
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Thalamocortical Transcriptional Gates Coordinate Memory Stabilization
NatureThe molecular mechanisms that enable memories to persist over long timescales from days to weeks and months are still poorly understood1. Here, to develop insights into this process, we created a behavioural task in which mice formed multiple memories but only consolidated some, while forgetting others, over the span of weeks. We then monitored circuit-
Priya Rajasethupathy +2 more
exaly +4 more sources
Potential memory and hysteretic effects in transcription
Journal of Theoretical Biology, 1988Kinetic results of RNA-chain elongation catalysed by wheat-germ RNA polymerase II are analysed according to the concept that DNA-dependent conformational transitions of the transcription complex intervene during transcription. A model is presented, involving participation of several forms of the transcription complex with different catalytic properties,
D, Job, J M, Soulié, C, Job, D, Shire
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Transcriptional Regulation Involved in Fear Memory Reconsolidation
Journal of Molecular Neuroscience, 2018Memory reconsolidation has been demonstrated to offer a potential target period during which the fear memories underlying fear disorders can be disrupted. Reconsolidation is a labile stage that consolidated memories re-enter after memories are reactivated.
Xu Wang +6 more
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Role of a transcription factor (CREB) in memory processes.
Rivista di biologia, 1998Memory storage includes a short-term phase (STM) which requires the phosphorylation of pre-existing proteins, and a long-term phase (LTM) which needs the novel synthesis of RNA and proteins. Cyclic AMP and a specific transcription factor (cAMP response element binding protein or CREB) play a central role in the formation of LTM in aplysia, drosophila ...
De Luca, Antonella, Giuditta, Antonio
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