Results 1 to 10 of about 430,900 (261)

Drosophila Piwi distinguishes transposons from mRNAs by piRNA complementarity and abundance

Cell Reports
Summary: Piwi-interacting RNAs (piRNAs) are the main repressors of transposable elements (TEs) in animal germlines. In Drosophila, Piwi-piRNA complexes associate with nascent TE transcripts to drive heterochromatin formation and TE repression.
Masaru Ariura, Therese Solberg, Hirotsugu Ishizu, Hazuki Takahashi, Piero Carninci, Haruhiko Siomi, Yuka W. Iwasaki   +6 more
doaj   +1 more source

Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues

Genome Biology
Background The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues.
Mario Acera-Mateos, Xian Adiconis, Jessica-Kanglin Li, Domenica Marchese, Ginevra Caratù, Chung-Chau Hon, Prabha Tiwari, Miki Kojima, Beate Vieth, Michael A. Murphy, Sean K. Simmons, Thomas Lefevre, Irene Claes, Christopher L. O’Connor, Rajasree Menon, Edgar A. Otto, Yoshinari Ando, Katy Vandereyken, Matthias Kretzler, Markus Bitzer, Ernest Fraenkel, Thierry Voet, Wolfgang Enard, Piero Carninci, Holger Heyn, Joshua Z. Levin, Elisabetta Mereu   +26 more
doaj   +1 more source

Genomic biomarkers to predict response to atezolizumab plus bevacizumab immunotherapy in hepatocellular carcinoma: Insights from the IMbrave150 trial [PDF]

Clinical and Molecular Hepatology
Background/Aims Combination immunotherapy, exemplified by atezolizumab plus bevacizumab, has become the standard of care for inoperable hepatocellular carcinoma (HCC).
Sun Young Yim, Sung Hwan Lee, Seung-Woo Baek, Bohwa Sohn, Yun Seong Jeong, Sang-Hee Kang, Kena Park, Hyewon Park, Sunyoung S. Lee, Ahmed O. Kaseb, Young Nyun Park, Sun-Hee Leem, Michael A. Curran, Ji Hoon Kim, Ju-Seog Lee   +14 more
doaj   +1 more source

Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development

Basic and Clinical Neuroscience, 2021
Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.
Mona Zamanian Azodi, Mostafa Rezaei Tavirani, Majid Rezaei Tavirani, Mohammad Rostami Nejad   +3 more
doaj  

Quantification of DNA probes on nylon microarrays using T4 polynucleotide kinase labeling

BioTechniques, 2003
M. El Atifi, I. Dupré, B. Rostaing, A.L. Benabid, F. Berger   +4 more
doaj   +1 more source

Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress

eLife
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins.
Jia-Hua Qu, Khalid Chakir, Kirill V Tarasov, Daniel R Riordon, Maria Grazia Perino, Allwin Jennifa Silvester, Edward G Lakatta   +6 more
doaj   +1 more source

Unraveling the transcriptional features and gene expression networks of pathogenic and saprotrophic Ophiostoma species during the infection of Ulmus americana

Microbiology Spectrum
American elm (Ulmus americana), highly prized for its ornamental value, has suffered two successive outbreaks of Dutch elm disease (DED) caused by ascomycete fungi belonging to the genus Ophiostoma.
Thais C. de Oliveira, Nastasia J. Freyria, Jorge Luis Sarmiento-Villamil, Ilga Porth, Philippe Tanguay, Louis Bernier   +5 more
doaj   +1 more source

Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity in Cerrena unicolor 87613

Microbiology Spectrum
The white rot fungus Cerrena unicolor 87613 has been previously shown to be a promising resource in laccase production, an enzyme with significant biotechnological applications. Conventional methods face technical challenges in improving laccase activity.
Long-Bin Zhang, Ting-Ting Qiu, Xiu-Gen Qiu, Wu-Wei-Jie Yang, Xiu-Yun Ye, Chun Meng   +5 more
doaj   +1 more source

Differential immunological responses in lamb rumen and colon to alfalfa hay and wheat straw in a concentrate-rich diet: insights into microbe-host interactions

mSystems
The impact of a concentrate-rich (CR) diet on the gut microbiome and epithelium homeostasis is well documented. However, it has not been systematically studied whether and how host-microbial interaction contributes to the immune homeostasis in the rumen ...
Kefyalew Gebeyew, Hui Mi, Yong Liu, Yongbin Liu, Biao Wang, Teka Feyera, Tan Zhiliang, Zhixiong He   +7 more
doaj   +1 more source

MULTIMODAL PROFILING OF DEVELOPING PURKINJE CELLS USING PATCH SEQ

IBRO Neuroscience Reports, 2023
Elena Baz Badillo, Vanessa Rouglan, Alexandre Favereaux, Mathieu Letellier   +3 more
doaj   +1 more source