Results 111 to 120 of about 8,166 (222)

Methyl-TWAS: A powerful method for in silico transcriptome-wide association studies (TWAS) using long-range DNA methylation [PDF]

, 2023
Soyeon Kim, Yidi Qin, Hyun Jung Park, Molin Yue, Zhongli Xu, Erick Forno, Wei Chen, Juan C. Celedón   +7 more
openalex   +1 more source

Transcriptome-wide association study of cardiovascular outcomes in chronic kidney disease: The chronic renal insufficiency cohort

HGG Advances
Summary: Transcriptome-wide association studies (TWASs) are powerful for identifying gene-trait associations by integrating gene expression and genome-wide association data, but findings may be impacted by the choice of gene expression reference.
Bridget M. Lin, Jia Wen, Andrea R.V.R. Horimoto, Lingbo Zhou, Shuai Huang, Mirela Dobre, Alan S. Go, Yun Li, Nora Franceschini, Amanda H. Anderson, Lawrence J. Appel, Jing Chen, Debbie L. Cohen, Laura M. Dember, Alan S. Go, James P. Lash, Mahboob Rahman, Panduranga S. Rao, Vallabh O. Shah, Mark L. Unruh   +19 more
doaj   +1 more source

A Modification to Two‐Stage Least Squares With Genetic Applications

Statistics in Medicine, Volume 44, Issue 25-27, November 2025.
ABSTRACT Two‐stage least squares (2SLS) is by default applied to infer a putative causal association between an exposure, such as a gene or a protein, with an outcome such as a complex disease or trait, in transcriptome‐ or proteome‐wide association studies (TWAS/PWAS).
Lei Fang, Wei Pan
wiley   +1 more source

A Self‐Assembling Peptide with Nanoparticle‐to‐Fibril Transformation Exhibits Multimodal Antimicrobial Activity through Membrane Disruption and Quorum‐Sensing Inhibition

Small, Volume 21, Issue 44, November 6, 2025.
A self‐assembling peptide that transforms from nanoparticles into bacterial‐entrapping nanofibrils and targets multi‐drug‐resistant pathogens through a dual mechanism. It disrupts bacterial membranes and strongly inhibits the quorum‐sensing system, a crucial factor in biofilm formation and virulence.
James Mwangi, Demeke Asmamaw, Min Yang, Dawit Adisu Tadese, Brenda B. Michira, Yi Wang, Sheng‐wen Zhou, Gan Wang, Ziyi Wang, Qiu‐Min Lu, Ren Lai   +10 more
wiley   +1 more source

GmSop20 Functions as a Key Coordinator of the Oil‐To‐Protein Ratio in Soybean Seeds

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study investigates the seed oil‐to‐protein ratio as a comprehensive quality metric and identifies GmSop20 as a crucial regulatory gene through forward genetics methodologies. By integrating GmSop20 with superior haplotypes and using gene editing/overexpression, new strategies are provided for precisely tuning the seed oil‐to‐protein ratio, thereby
Haowei Zheng, Xinkang Feng, Longlong Wang, Wentao Shao, Shiyu Guo, Duo Zhao, Jiajia Li, Long Yan, Long Miao, Bincheng Sun, Huihui Gao, Hongmei Qiu, Yu Hu, Linlin Kong, Robert M. Stupar, Ying‐hui Li, Li‐juan Qiu, Xiaobo Wang   +17 more
wiley   +1 more source

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework

Cell Genomics
Summary: Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data.
Yichao Zhou, Temidayo Adeluwa, Lisha Zhu, Sofia Salazar-Magaña, Sarah Sumner, Hyunki Kim, Saideep Gona, Festus Nyasimi, Rohit Kulkarni, Joseph E. Powell, Ravi Madduri, Boxiang Liu, Mengjie Chen, Hae Kyung Im   +13 more
doaj   +1 more source

GRPa‐PRS: A risk stratification method to identify genetically‐regulated pathways in polygenic diseases

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Polygenic risk score (PRS) assesses genetic risk for diseases, yet some high‐risk individuals avoid illness while low‐risk individuals develop it. We hypothesize that unknown counterfactors may reverse PRS predictions, offering insights into disease mechanisms and interventions.
Xiaoyang Li, Brisa S. Fernandes, Andi Liu, Jingchun Chen, Xiangning Chen, Zhongming Zhao, Yulin Dai   +6 more
wiley   +1 more source

Unveiling novel susceptibility genes and drug targets for basal cell carcinoma by a cross-tissue transcriptome-wide association study

Discover Oncology
To identify novel susceptibility genes and drug targets for basal cell carcinoma (BCC). We performed a transcriptome-wide association study (TWAS) to identified the susceptibility genes and potential drug targets for BCC.
Hong Sun, Ling Li, Xiu Xin, Jingchao Yan, Taomin Huang   +4 more
semanticscholar   +1 more source

Multi-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub

Ecotoxicology and Environmental Safety
Air pollution, particularly fine particulate matter and gaseous pollutants including NO2 and NOx, presents significant public health challenges. While the harmful effects of these pollutants are well-documented, the molecular mechanisms underlying their ...
Wei Liu, Tong Liu, Xinxin Si, Jiaxing Liang, Xia Yan, Juexin Zhang, Bing Pang, Wenmin Luo, Junhong Liu, Huazhe Yang, Peng Shi   +10 more
doaj   +1 more source

Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study

Frontiers in Genetics
Background Genome-wide association studies (GWASs) have identified 38 loci associated with ulcerative colitis (UC) susceptibility, but the risk genes and their biological mechanisms remained to be comprehensively elucidated. Methods Multi-marker analysis
Shijie Ren, Chaodi Sun, Wenjing Zhai, Wenli Wei, Jianping Liu   +4 more
semanticscholar   +1 more source