Results 121 to 130 of about 8,166 (222)

Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta-analyses:The Long Life Family Study [PDF]

Patients with chronic kidney disease (CKD) have increased oxidative stress and chronic inflammation, which may escalate the production of advanced glycation end-products (AGEs).
Acharya, Sandeep, Brent, Michael R., Christensen, Kaare, Feitosa, Mary F., Kuipers, Allison L., Kulminski, Alexander M, Lin, Shiow J., Province, Michael A., Thyagarajan, Bharat, Wojczynski, Mary K., Zmuda, Joseph M.   +10 more
core   +1 more source

Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer’s disease

Translational Psychiatry
The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and genetic risks.
Jing Tian, Kun Jia, Tienju Wang, Lan Guo, Zhenyu Xuan, Elias K. Michaelis, R. Swerdlow, Heng Du   +7 more
semanticscholar   +1 more source

Unraveling the genetic landscape of susceptibility to multiple primary cancers. [PDF]

With advances in cancer screening and treatment, there is a growing population of cancer survivors who may develop subsequent primary cancers. While hereditary cancer syndromes account for only a portion of multiple cancer cases, we sought to explore the
Alexeeff, Stacey, Cavazos, Taylor, Corley, Douglas, Graff, Rebecca, Habel, Laurel, Hoffmann, Thomas, Kachuri, Linda, Kushi, Lawrence, Middha, Pooja, Nierenberg, Jovia, Sakoda, Lori, Van Den Eeden, Stephen, Witte, John, Zhang, Jie, Ziv, Elad   +14 more
core   +1 more source

Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract

Frontiers in Ophthalmology
Introduction Cataract is the leading cause of blindness among the elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up to 58%.
H. Choquet, Matthieu Duot, Victor A. Herrera, Sanjaya K. Shrestha, Travis J Meyers, Thomas J. Hoffmann, P. Sangani, S. Lachke   +7 more
semanticscholar   +1 more source

TWAS facilitates gene-scale trait genetic dissection through gene expression, structural variations, and alternative splicing in soybean [PDF]

A genome-wide association study (GWAS) identifies trait-associated loci, but identifying the causal genes can be a bottleneck, due in part to slow decay of linkage disequilibrium (LD). A transcriptome-wide association study (TWAS) addresses this issue by
Gao, Huawei, Hong, Huilong, Li, Delin, Li, Yan-Fei, Li, Ying-Hui, Liu, Bin, Lyv, Xiangguang, Qiu, Li-Juan, Schnable, James C., Schnable, Patrick S., Tian, Yu, Wang, Jiajun, Wang, Qi, Wang, Ruizhen, Yang, Jinliang, Zhang, Hao, Zhao, Chaosen   +16 more
core   +1 more source

Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach [PDF]

Background and Hypothesis: Investigating the shared brain protein and genetic components of schizophrenia (SCZ) and bipolar I disorder (BD-I) presents a unique opportunity to understand the underlying pathophysiological processes and pinpoint potential ...
Deng, Wei, Guo, Wanjun, Hu, Xun, Li, Ming, Li, Tao, Li, Xiaojing, Sham, Pak Chung, Wang, Qiang, Xiao, Xiao, Yang, Zhi Hui, Zhang, Chengcheng, Zhao, Liansheng   +11 more
core   +1 more source

Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives

Cell & Bioscience
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS)
Keyu Jia, Jun Shen
doaj   +1 more source

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
doaj   +1 more source

Transcriptome-Wide Association Study Reveals Potentially Candidate Genes Responsible for Milk Production Traits in Buffalo

International Journal of Molecular Sciences
Identifying key causal genes is critical for unraveling the genetic basis of complex economic traits, yet it remains a formidable challenge. The advent of large-scale sequencing data and computational algorithms, such as transcriptome-wide association ...
Kelong Wei, Ying Lu, Xiaoya Ma, Anqian Duan, Xing-rong Lu, H. Abdel-Shafy, T. Deng   +6 more
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for frailty

Frontiers in Genetics
Background: Although genome-wide association studies (GWAS) have identified 14 loci associated with frailty index (FI) susceptibility, the underlying causative genes and biological mechanisms remain elusive.
Daoyi Lin, Shuyan Wu, Wangyu Li, Peng Ye, Xuan Pan, Ting Zheng, Fei Gao   +6 more
semanticscholar   +1 more source