Results 121 to 130 of about 928,042 (281)

The Olfactory Transcriptomes of Mice

PLoS Genetics, 2014
The olfactory (OR) and vomeronasal receptor (VR) repertoires are collectively encoded by 1700 genes and pseudogenes in the mouse genome. Most OR and VR genes were identified by comparative genomic techniques and therefore, in many of those cases, only their protein coding sequences are defined.
Ximena Ibarra-Soria, Luis R. Saraiva, Darren W. Logan, Maria O. Levitin   +3 more
openaire   +5 more sources

Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells

Haematologica, 2018
Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene ...
Stefanie C. Herkt, Olga N. Kuvardina, Julia Herglotz, Lucas Schneider, Annekarin Meyer, Claudia Pommerenke, Gabriela Salinas-Riester, Erhard Seifried, Halvard Bonig, Jörn Lausen   +9 more
doaj   +1 more source

Transcriptome and Temporal Transcriptome Analyses in Single Cells

International Journal of Molecular Sciences
Transcriptome analysis in single cells, enabled by single-cell RNA sequencing, has become a prevalent approach in biomedical research, ranging from investigations of gene regulation to the characterization of tissue organization. Over the past decade, advances in single-cell RNA sequencing technology, including its underlying chemistry, have ...
Jun Lyu, Chongyi Chen
openaire   +2 more sources

Pan-cancer genome and transcriptome analyses of 1,699 pediatric leukemias and solid tumors

Nature, 2018
Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages.
Xiaotu Ma, Yu Liu, Yanling Liu, L. Alexandrov, Michael N. Edmonson, Charles Gawad, Xin Zhou, Yongjin Li, Michael C. Rusch, J. Easton, R. Huether, V. Gonzalez-Pena, M. Wilkinson, L. Hermida, Sean Davis, Edgar Sioson, S. Pounds, Xueyuan Cao, R. Ries, Zhaoming Wang, Xiang Chen, Li Dong, S. Diskin, Malcolm A. Smith, J. G. Auvil, P. Meltzer, C. Lau, E. Perlman, J. Maris, Soheil Meschinchi, S. Hunger, D. Gerhard, Jinghui Zhang   +32 more
semanticscholar   +1 more source

The plasticity of the mammalian transcriptome

Genomics, 2010
The dogmatic view of RNA as a mere necessity in the transfer of information between DNA and proteins has during recent years come into question. Novel approaches and new technology has revealed an unprecedented level of inherent complexity in the mammalian transcriptome.
Johan Lindberg, Joakim Lundeberg
openaire   +3 more sources

The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

eLife, 2017
The retinoblastoma Rb protein is an important factor controlling the cell cycle. Yet, mammalian cells carrying Rb deletions are still able to arrest under growth-limiting conditions.
Christina FS Mages, Axel Wintsche, Stephan H Bernhart, Gerd A Müller   +3 more
doaj   +1 more source

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Aging Cell, 2015
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age‐related chronic diseases.
Yi Zhu, T. Tchkonia, T. Pirtskhalava, A. Gower, H. Ding, N. Giorgadze, Allyson K. Palmer, Y. Ikeno, G. Hubbard, M. Lenburg, S. O’Hara, N. LaRusso, Jordan D. Miller, Carolyn M. Roos, Grace C. Verzosa, N. LeBrasseur, J. Wren, J. Farr, S. Khosla, Michael B. Stout, S. McGowan, Heike Fuhrmann-Stroissnigg, Aditi U. Gurkar, J. Zhao, D. Colangelo, A. Dorronsoro, Y. Ling, Amira S Barghouthy, D. C. Navarro, T. Sano, P. Robbins, L. Niedernhofer, J. Kirkland   +32 more
semanticscholar   +1 more source

Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology

Bioinform., 2019
Motivation The composition and density of immune cells in the tumor microenvironment (TME) profoundly influence tumor progression and success of anti-cancer therapies.
G. Sturm, F. Finotello, F. Petitprez, J. Zhang, J. Baumbach, W. Fridman, M. List, T. Aneichyk   +7 more
semanticscholar   +1 more source

Comparative genomics reveals conservative evolution of the xylem transcriptome in vascular plants

BMC Evolutionary Biology, 2010
Background Wood is a valuable natural resource and a major carbon sink. Wood formation is an important developmental process in vascular plants which played a crucial role in plant evolution.
Wu Harry X, Li Xinguo, Southerton Simon G   +2 more
doaj   +1 more source

Single-nucleotide resolution mapping of m6A and m6Am throughout the transcriptome

Nature Methods, 2015
N6-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A residues to transcript regions 100–200 nt long but cannot identify precise m6A ...
Bastian Linder, Anya V. Grozhik, Anthony O. Olarerin-George, Cem Meydan, C. Mason, S. Jaffrey   +5 more
semanticscholar   +1 more source