Results 121 to 130 of about 426,916 (271)

Serial microanalysis of renal transcriptomes

open access: green, 1999
Bérangère Virlon   +5 more
openalex   +1 more source

Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa

open access: yesAdvanced Materials, EarlyView.
Base editing using nanoneedles efficiently corrects pathogenic variants in the type VII collagen gene of primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. Nanoneedle editing induces minimal and reversible transcriptional perturbations while restoring the production and secretion of functional type VII collagen.
Salman Ahmad Mustfa   +10 more
wiley   +1 more source

SpaRED benchmark: Enhancing Gene Expression Prediction from Histology Images with Spatial Transcriptomics Completion [PDF]

open access: yesarXiv
Spatial Transcriptomics is a novel technology that aligns histology images with spatially resolved gene expression profiles. Although groundbreaking, it struggles with gene capture yielding high corruption in acquired data. Given potential applications, recent efforts have focused on predicting transcriptomic profiles solely from histology images ...
arxiv  

Correlation between Bacillus subtilis scoC Phenotype and Gene Expression Determined Using Microarrays for Transcriptome Analysis [PDF]

open access: green, 2001
R M Caldwell   +5 more
openalex   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

open access: yesAdvanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu   +4 more
wiley   +1 more source

Spatial Transcriptomics Iterative Hierarchical Clustering (stIHC): A Novel Method for Identifying Spatial Gene Co-Expression Modules [PDF]

open access: yesarXiv
Recent advancements in spatial transcriptomics technologies allow researchers to simultaneously measure RNA expression levels for hundreds to thousands of genes while preserving spatial information within tissues, providing critical insights into spatial gene expression patterns, tissue organization, and gene functionality.
arxiv  

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

open access: yesAdvanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou   +10 more
wiley   +1 more source

Transcriptome and genome analysis of single disseminated tumor cells: approach to study minimal residual cancer [PDF]

open access: bronze, 2001
Christoph A. Klein   +5 more
openalex   +1 more source

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