Results 181 to 190 of about 963,153 (378)

Quantification of DNA probes on nylon microarrays using T4 polynucleotide kinase labeling

BioTechniques, 2003
M. El Atifi, I. Dupré, B. Rostaing, A.L. Benabid, F. Berger   +4 more
doaj   +1 more source

Transcriptome of a mouse kidney cortical collecting duct cell line: Effects of aldosterone and vasopressin [PDF]

, 2001
Maya Robert-Nicoud, Marjorie Flahaut, Jean‐Marc Elalouf, M Nicod, Miguel Salinas, Marcelle Bens, Alain Doucet, Patrick Wincker, François Artiguenave, Jean‐Daniel Horisberger, Alain Vandewalle, Bernard C. Rossier, Dmitri Firsov   +12 more
openalex   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress

eLife
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins.
Jia-Hua Qu, Khalid Chakir, Kirill V Tarasov, Daniel R Riordon, Maria Grazia Perino, Allwin Jennifa Silvester, Edward G Lakatta   +6 more
doaj   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Unraveling the transcriptional features and gene expression networks of pathogenic and saprotrophic Ophiostoma species during the infection of Ulmus americana

Microbiology Spectrum
American elm (Ulmus americana), highly prized for its ornamental value, has suffered two successive outbreaks of Dutch elm disease (DED) caused by ascomycete fungi belonging to the genus Ophiostoma.
Thais C. de Oliveira, Nastasia J. Freyria, Jorge Luis Sarmiento-Villamil, Ilga Porth, Philippe Tanguay, Louis Bernier   +5 more
doaj   +1 more source

Correlation between Bacillus subtilis scoC Phenotype and Gene Expression Determined Using Microarrays for Transcriptome Analysis [PDF]

, 2001
R M Caldwell, Ron Sapolsky, Walter Weyler, Randal R. Maile, S C Causey, E Ferrari   +5 more
openalex   +1 more source

A pathology atlas of the human cancer transcriptome

Science, 2017
M. Uhlén, Cheng Zhang, Sunjae Lee, E. Sjöstedt, Linn Fagerberg, G. Bidkhori, Rui Benfeitas, M. Arif, Zhengtao Liu, F. Edfors, Kemal Sanli, K. von Feilitzen, P. Oksvold, E. Lundberg, S. Hober, P. Nilsson, J. Mattsson, J. Schwenk, H. Brunnström, B. Glimelius, T. Sjöblom, Per-Henrik D. Edqvist, Dijana Djureinovic, P. Micke, C. Lindskog, A. Mardinoğlu, F. Pontén   +26 more
semanticscholar   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity in Cerrena unicolor 87613

Microbiology Spectrum
The white rot fungus Cerrena unicolor 87613 has been previously shown to be a promising resource in laccase production, an enzyme with significant biotechnological applications. Conventional methods face technical challenges in improving laccase activity.
Long-Bin Zhang, Ting-Ting Qiu, Xiu-Gen Qiu, Wu-Wei-Jie Yang, Xiu-Yun Ye, Chun Meng   +5 more
doaj   +1 more source