Results 181 to 190 of about 474,674 (279)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Multi-Omics Analyses Reveal Divergent Molecular Mechanisms Underlying Plant Biomass Conversion by Five Fungi. [PDF]

Microbiologyopen
Peng M, Li J, Xu L, Chroumpi T, Garrigues S, Kun RS, Meng J, Aguilar-Pontes MV, Lipzen A, Ng V, Clendinen CS, Tolic N, Baker SE, Grigoriev IV, de Vries RP.   +14 more
europepmc   +1 more source

Additional file 1: of Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

, 2019
Sehhoon Park, Je‐Gun Joung, Yang Won Min, Jae‐Yong Nam, Daeun Ryu, Dongryul Oh, Woong‐Yang Park, Se‐Hoon Lee, Yoon‐La Choi, Jin Seok Ahn, Myung‐Ju Ahn, Keunchil Park, Jong‐Mu Sun   +12 more
openalex   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair. [PDF]

Immun Ageing
Martin LE, Barr JS, Cartailler JP, Shrestha S, Estévez-Lao TY, Hillyer JF.   +5 more
europepmc   +1 more source

Additional file 4: Table S4. of Transcriptome profiling reveals the genetic basis of alkalinity tolerance in wheat

, 2017
Meng Chen, Taiyong Quan, Zhongyi Li, Kangli Cui, Yan Li, Liang Yu, Jiulan Dai, Guangmin Xia, Shuwei Liu   +8 more
openalex   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Transcriptome characterization and population genetics of <i>Ludisia discolor</i> (Ker Gawl.) A.Rich (Orchidaceae): implication for its conservation in Vietnam. [PDF]

Biodivers Data J
Phan HT, Thi-Lan N, Le OK, Nguyen CQ, Trinh CTN, Ha YH, Shah SNM, Vu DD.   +7 more
europepmc   +1 more source

Additional file 3 of Transcriptome analysis reveals the roles of stem nodes in cadmium transport to rice grain

, 2020
Ailing Liu, Zhibo Zhou, Yake Yi, Guanghui Chen   +3 more
openalex   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source