Results 11 to 20 of about 426,916 (271)

Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring

open access: yesJournal of Fungi, 2021
Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood
François Danion   +11 more
doaj   +1 more source

Induced Pluripotent Stem Cell Generation-Associated Point Mutations Arise during the Initial Stages of the Conversion of These Cells

open access: yesStem Cell Reports, 2014
A large number of point mutations have been identified in induced pluripotent stem cell (iPSC) genomes to date. Whether these mutations are associated with iPSC generation is an important and controversial issue.
Mayumi Sugiura   +8 more
doaj   +1 more source

Fruit fly phylogeny imprints bacterial gut microbiota

open access: yesEvolutionary Applications, 2022
One promising avenue for reconciling the goals of crop production and ecosystem preservation consists in the manipulation of beneficial biotic interactions, such as between insects and microbes.
Virginie Ravigné   +6 more
doaj   +1 more source

Human mast cell activation through Fc receptors and Toll-like receptors

open access: yesAllergology International, 2004
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE.
Yoshimichi Okayama   +7 more
doaj   +1 more source

BAT: Bisulfite Analysis Toolkit [version 1; referees: 2 approved]

open access: yesF1000Research, 2017
Here, we present BAT, a modular bisulfite analysis toolkit, that facilitates the analysis of bisulfite sequencing data. It covers the essential analysis steps of read alignment, quality control, extraction of methylation information, and calling of ...
Helene Kretzmer   +2 more
doaj   +1 more source

Palindrome-mediated Translocations in Humans: A New Mechanistic Model for Gross Chromosomal Rearrangements

open access: yesFrontiers in Genetics, 2016
Palindromic DNA sequences, which can form secondary structures, are widely distributed in the human genome. Although the nature of the secondary structure—single-stranded hairpin or double-stranded cruciform—has been extensively investigated in vitro ...
Hidehito Inagaki   +8 more
doaj   +1 more source

SpaceTx: A Roadmap for Benchmarking Spatial Transcriptomics Exploration of the Brain [PDF]

open access: yesarXiv, 2023
Mapping spatial distributions of transcriptomic cell types is essential to understanding the brain, with its exceptional cellular heterogeneity and the functional significance of its spatial organization. Spatial transcriptomics techniques are hoped to accomplish these measurements, but each method uses different experimental and computational ...
arxiv  

Role of the Solute-Binding Protein CuaD in the Signaling and Regulating Pathway of Cellobiose and Cellulose Utilization in Ruminiclostridium cellulolyticum

open access: yesMicroorganisms, 2023
In Ruminiclostridium cellulolyticum, cellobiose is imported by the CuaABC ATP-binding cassette transporter containing the solute-binding protein (SBP) CuaA and is further degraded in the cytosol by the cellobiose phosphorylase CbpA.
Aurélie Fosses   +7 more
doaj   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls   +9 more
wiley   +1 more source

Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene

open access: yesBMC Genomics, 2020
Background Protein Disulfide Isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily with crucial roles in endoplasmic reticulum proteostasis, implicated in many diseases.
Daniela Kajihara   +9 more
doaj   +1 more source

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