Results 241 to 250 of about 963,153 (378)

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Impact of steroid differentiation on tumor microenvironment revealed by single-nucleus atlas of adrenal tumors. [PDF]

Nat Commun
Jouinot A, Martin Y, Violon F, Foulonneau T, Bendjelal Y, Calvet P, Izac B, Letourneur F, Bertholle C, Andrieu M, Onifarasoaniaina R, Favier M, de Guitaut C, Fraikin A, de Murat D, Armignacco R, Benanteur N, Birtolo MF, Sibony M, Perlemoine K, Vaduva P, Bouys L, Bonnet-Serrano F, Dousset B, Gaillard M, Pasmant E, Barat M, Dohan A, Haissaguerre M, Tabarin A, Libé R, Guignat L, Groussin L, Berthon A, Ragazzon B, Bertherat J, Assié G.   +36 more
europepmc   +1 more source

Quantitative profiling of pseudouridylation landscape in the human transcriptome

bioRxiv, 2022
Meiling Zhang, Zhe Jiang, Yichen Ma, Wenqing Liu, Zhuang Yuan, Bo Lu, Kai Li, Jinying Peng, C. Yi   +8 more
semanticscholar   +1 more source

CCL5hi Macrophages Interact with CD8+ T Cells and Potentiate Responsiveness to PD‐1 Blockade Plus Chemotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study has characterized a functionally distinct macrophage subset, termed CCL5hi macrophages, and elucidated the underlying mechanisms of a regulatory feedback loop that interconnects IFN‐γ, CCL5hi macrophages, and CD8+ T cells within the TME of ESCC undergoing immunochemotherapy.
Yuanzhen Ma, Xiaodong Su, Tingting Zeng, Chunlian Zhou, Guozhen Yang, Zengfei Xia, Chufeng Zeng, Jiarong Zhan, Xin‐Yuan Guan, Xu Zhang, Yan Li   +10 more
wiley   +1 more source

Development of SSR Markers and Genetic Diversity Analysis of <i>Musa basjoo</i> Using Transcriptome Sequencing. [PDF]

Ecol Evol
Zhang J, Yang C, Yang X, Lei J, Long P.
europepmc   +1 more source

The dynamics of theSaccharomyces carlsbergensisbrewing yeast transcriptome during a production-scale lager beer fermentation [PDF]

, 2002
Kjeld Olesen, T FELDING, Claes Gjermansen, Josie Hansen   +3 more
openalex   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

X-linked transcriptome dysregulation across immune cells in systemic lupus erythematosus. [PDF]

Biol Sex Differ
Soares M, Wemans IS, Caldas P, da Rocha ST, Grosso AR.   +4 more
europepmc   +1 more source

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

Evaluating the potential and limitations of nanopore adaptive sampling for targeted transcriptome sequencing. [PDF]

Genome Biol
DeBruyne N, Wang F, Xu Y, Lin L.
europepmc   +1 more source