Results 261 to 270 of about 426,916 (271)

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Transcriptome size matters for single-cell RNA-seq normalization and bulk deconvolution. [PDF]

Nat Commun
Lu S, Yang J, Yan L, Liu J, Wang JJ, Jain R, Yu J.   +6 more
europepmc   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

Single-cell dual-omics reveals translational and transcriptional landscapes and regulations in oocytes from ovarian endometriosis patients. [PDF]

Front Endocrinol (Lausanne)
Diao X, Huang J, Xiang R, Zhuang S, Liang Q, Liang X, Zeng H.   +6 more
europepmc   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

The Exon-Based Transcriptomic Analysis of Parkinson's Disease. [PDF]

Biomolecules
Kõks S.
europepmc   +1 more source

Editorial: Spatial transcriptome and single-cell sequencing for exploring molecular mechanisms of neuroimmunity and discovering novel markers of neurological diseases. [PDF]

Front Neurol
Wang B, Shi Y, Cheng C, Song J, Pan Y.
europepmc   +1 more source

Retraction: Dynamic interplay of innate and adaptive immunity during sterile retinal inflammation: insights from the transcriptome. [PDF]

Front Immunol
Frontiers Editorial Office.
europepmc   +1 more source

Metabolome and transcriptome analyses for explore heat stress responses and adaptation mechanisms in Rhododendron henanense subsp. lingbaoense. [PDF]

BMC Plant Biol
Li Y, Li X, Lei M, Han J, Huang Z, Zhang K, Yang Y, Yang N, Yu X, Zhou X.   +9 more
europepmc   +1 more source

Mouse-Geneformer: A deep learning model for mouse single-cell transcriptome and its cross-species utility. [PDF]

PLoS Genet
Ito K, Hirakawa T, Shigenobu S, Fujiyoshi H, Yamashita T.   +4 more
europepmc   +1 more source