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Evolution of the unspliced transcriptome [PDF]
BMC Evolutionary Biology, 2015 Despite their abundance, unspliced EST data have received little attention as a source of information on non-coding RNAs. Very little is know, therefore, about the genomic distribution of unspliced non-coding transcripts and their relationship with the much better studied regularly spliced products. In particular, their evolution has remained virtually
Engelhardt, Jan, Stadler, Peter F.
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Gene Regulation and Transcriptomics [PDF]
Current Issues in Molecular Biology, 2021 Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition from a vertebrate host to a tick vector and transmission from a tick vector to a vertebrate host.
Samuels, D. Scott +8 more
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De novo transcriptome sequencing in Bixa orellana to identify genes involved in methylerythritol phosphate, carotenoid and bixin biosynthesis. [PDF]
, 2015 BackgroundBixin or annatto is a commercially important natural orange-red pigment derived from lycopene that is produced and stored in seeds of Bixa orellana L.
Aguilar-Espinosa, Margarita +5 more
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Frontiers in Genetics, 2016 Palindromic DNA sequences, which can form secondary structures, are widely distributed in the human genome. Although the nature of the secondary structure—single-stranded hairpin or double-stranded cruciform—has been extensively investigated in vitro ...
Hidehito Inagaki +8 more
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Journal of Neuroscience, 2008 Understanding the cell–cell interactions that control CNS development and function has long been limited by the lack of methods to cleanly separate neural cell types.
John D. Cahoy +11 more
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The Human Mitochondrial Transcriptome [PDF]
Cell, 2011 The human mitochondrial genome comprises a distinct genetic system transcribed as precursor polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, tRNAs, and rRNAs. Here, we provide a comprehensive analysis of the human mitochondrial transcriptome across multiple cell lines and tissues.
Mercer, Tim R. +11 more
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Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+
Nature, 2019 Imaging the transcriptome in situ with high accuracy has been a major challenge in single-cell biology, which is particularly hindered by the limits of optical resolution and the density of transcripts in single cells1–5. Here we demonstrate an evolution
C. L. Eng +10 more
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Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
Nature Neuroscience, 2020 We used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex.
K. E. Maynard +17 more
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Transcriptomics in toxicology [PDF]
Food and Chemical Toxicology, 2017 Xenobiotics, of which many are toxic, may enter the human body through multiple routes. Excessive human exposure to xenobiotics may exceed the body's capacity to defend against the xenobiotic-induced toxicity and result in potentially fatal adverse health effects.
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Bayesian transcriptome assembly [PDF]
Genome Biology, 2014 AbstractRNA sequencing allows for simultaneous transcript discovery and quantification, but reconstructing complete transcripts from such data remains difficult. Here, we introduce Bayesembler, a novel probabilistic method for transcriptome assembly built on a Bayesian model of the RNA sequencing process.
Sørensen, Lasse Maretty +2 more
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