Results 91 to 100 of about 22,603,228 (311)

Comparative Transcriptome Profiling Reveals Differential Defense Responses of Resistant and Susceptible Phalaenopsis to Dickeya fangzhongdai

Horticulturae
Soft rot caused by Dickeya fangzhongdai is a destructive disease in Phalaenopsis production that seriously impacts the quality and yield of Phalaenopsis.
Jingjing Xin, Jiyong Tang, Ying Mao, Dongdong Ren, Ping Luo, Yongyi Cui   +5 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Anthraquinone-2-Carboxylic Acid Is a Potential Antiviral Candidate Against Influenza Viruses In Vitro and In Vivo

Viruses
Seasonal outbreaks and occasional pandemics triggered by influenza viruses annually impose considerable burdens on public health and finances. The continual evolution of viral strains with drug resistance emphasizes the urgency of discovering novel ...
Sichen Ren, Yan Luo, Huimin Tao, Ping Wang, Song Li, Jingjing Yang   +5 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

mstudiva/Mcav-Cladocopium-Annotated-Transcriptome: Final Montastraea cavernosa/Cladocopium spp. transcriptome assembly

, 2020
<p>Includes the transcriptome annotation files needed for RNA-Seq analysis of the coral Montastraea cavernosa and algal symbionts of the genus Cladocopium spp.
Studivan Michael S
core   +1 more source

Transcriptome Analysis of Immune Response Against Edwardsiella tarda Infection in Spotted Sea Bass (Lateolabrax maculatus)

Fishes
Edwardsiella tarda is a gram-negative bacterium reported to be one of the most harmful pathogens in aquaculture. In this study, we conducted transcriptome profiling of the head kidney, liver, and spleen in spotted sea bass (Lateolabrax maculatus ...
Zhaosheng Sun, Xia Li, Qingling Zhang, Wei Wang, Huan Wang, Tingshuang Pan, Qian Gao   +6 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The transcriptome of Nacobbus aberrans reveals insights into the evolution of sedentary endoparasitism in plant-parasitic nematodes [PDF]

, 2014
This work was supported by the Biotechnology and Biological Sciences Research Council and The James Hutton Institute (JHI). The James Hutton Institute receives funding from the Scottish Government.
Jones, John T., Cock, Peter J. A., Urwin, P.E., Eves-van den Akker, Sebastian, Cock, P.J.A., Danchin, Etienne, Danchin, Etienne G. J., Lilley, Catherine J., Urwin, Peter E., Jones, J.T., Lilley, C.J., Eves-van den Akker, S, Rancurel, Corinne   +12 more
core   +1 more source

Integrative transcriptomic profiling uncovers immune and functional responses to bisphenol a across multiple tissues in male mice

Animal Cells and Systems
Bisphenol A (BPA), an endocrine-disrupting substance commonly found in plastics and receipts, is associated with adverse effects, including endocrine disorders, reduced fertility, and metabolic issues.
Yejee Park, Min-Jae Jang, Do-Yeal Ryu, Byeonghwi Lim, Rajesh Kumar Pathak, Myung-Geol Pang, Jun-Mo Kim   +6 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source