Results 71 to 80 of about 397,925 (266)

Identification of a Highly Virulent Verticillium nonalfalfae Strain Vn011 and Expression Analysis of Its Orphan Genes During Potato Inoculation

Plants
Potato (Solanum tuberosum L.) is an important food crop and in recent years, Verticillium wilt has become one of the major diseases limiting potato production.
Mengyuan Wan, Xinlong Chen, Xiaoxi Yi, Yi Fu, Yuanliang Jin, Dianqiu Lyu   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exploring virulence and stress response in Entamoeba histolytica: insights from clinical strains

Microbiology Spectrum
Amebiasis, caused by the protozoan Entamoeba histolytica, is a significant parasitic infection affecting millions of people worldwide, particularly in developing regions.
Yasuaki Yanagawa, Manu Sharma, Shinji Izumiyama, Upinder Singh   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model

Drug Design, Development and Therapy, 2017
Song Guo,1,* Xiaowei Lu,1,* Ruihuan Gu,2 Di Zhang,3 Yijuan Sun,2 Yun Feng1 1Department of Obstetrics and Gynecology, Reproductive Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People’s ...
Guo S, Lu X, Gu R, Zhang D, Sun Y, Feng Y   +5 more
doaj  

Comparative Transcriptome Profiling Reveals Differential Defense Responses of Resistant and Susceptible Phalaenopsis to Dickeya fangzhongdai

Horticulturae
Soft rot caused by Dickeya fangzhongdai is a destructive disease in Phalaenopsis production that seriously impacts the quality and yield of Phalaenopsis.
Jingjing Xin, Jiyong Tang, Ying Mao, Dongdong Ren, Ping Luo, Yongyi Cui   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Anthraquinone-2-Carboxylic Acid Is a Potential Antiviral Candidate Against Influenza Viruses In Vitro and In Vivo

Viruses
Seasonal outbreaks and occasional pandemics triggered by influenza viruses annually impose considerable burdens on public health and finances. The continual evolution of viral strains with drug resistance emphasizes the urgency of discovering novel ...
Sichen Ren, Yan Luo, Huimin Tao, Ping Wang, Song Li, Jingjing Yang   +5 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Transcriptome Analysis of Immune Response Against Edwardsiella tarda Infection in Spotted Sea Bass (Lateolabrax maculatus)

Fishes
Edwardsiella tarda is a gram-negative bacterium reported to be one of the most harmful pathogens in aquaculture. In this study, we conducted transcriptome profiling of the head kidney, liver, and spleen in spotted sea bass (Lateolabrax maculatus ...
Zhaosheng Sun, Xia Li, Qingling Zhang, Wei Wang, Huan Wang, Tingshuang Pan, Qian Gao   +6 more
doaj   +1 more source