Results 111 to 120 of about 22,603,228 (311)

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Transcriptomic Profiling Provides Insight into the Molecular Basis of Heterosis in Philippine-Reared Bombyx mori Hybrids

Insects
In the Philippines, Bombyx mori parental strains Lat21 and B221 are crossed to yield NC144 and CN144, which demonstrate hybrid vigor. The molecular basis of the observed vigor in the hybrids is warranted, as it may assist in improving local sericulture ...
Ma. Ysabella Elaine D. Conde, Jose Planta, Ma. Anita M. Bautista   +2 more
doaj   +1 more source

The new phase of transcriptome analysis.

SEIBUTSU BUTSURI KAGAKU, 2006
The FANTOM Consortium analyzed over 2 million sequences of RNAs produced from the mouse genome, obtaining more than 100, 000 full length copies of these RNAs, and used several new technologies to generate more than 20 million tags representing their starts and ends in a technical tour-de-force that provides a amazing new view of our genome.
openaire   +3 more sources

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Improvement of Lactobacillus plantarum Aerobic Growth as Directed by Comprehensive Transcriptome Analysis [PDF]

, 2008
An aerobic Lactobacillus plantarum culture displayed growth stagnation during early growth. Transcriptome analysis revealed that resumption of growth after stagnation correlated with activation of CO2-producing pathways, suggesting that a limiting CO2 ...
Vos, W.M., de, Kleerebezem, M., Smid, E.J., Stevens, Marc J.A.,, Kuipers, Oscar P.; id_orcid, Oscar P. Kuipers, Smid, Eddy J.,, Kleerebezem, Michiel, Molenaar, D., Michiel Kleerebezem, Kuipers, Oscar P.,, Stevens, M.J.A., Kuipers, O.P., Marc J. A. Stevens, Molenaar, Douwe; id_orcid, Eddy J. Smid, Vos, Willem M. de, Vos, Willem M. de,, Douwe Molenaar, de Vos, W.M., Wiersma, Anne,, Molenaar, Douwe,, Wiersma, Anne, Kuipers, Oscar P., Smid, Eddy J., Anne Wiersma, de Vos, Willern M., Stevens, Marc J. A., Molenaar, Douwe, Willem M. de Vos, Kleerebezem, Michiel,, Wiersma, A.   +31 more
core   +3 more sources

Influences of Lactate on the High-density Fermentation by Bacillus licheniformis HK

Shipin gongye ke-ji
To improve the biomass and spore rate of Bacillus licheniformis HK, influences of lactate on cell growth and metabolism and spore production were investigated at a 20 L bioreactor, and lactate addition was conducted by coupling with pH7.0 from 16 h to 32
Yanmei ZHAO, Jiakang LU, Yueya SHI, Yanting WANG, Yanan HUANG, Xiong CHEN, Zhi WANG   +6 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

SuperSAGE : the drought stress-responsive transcriptome of chickpea roots [PDF]

, 2009
Background Drought is the major constraint to increase yield in chickpea (Cicer arietinum). Improving drought tolerance is therefore of outmost importance for breeding. However, the complexity of the trait allowed only marginal progress.
Matsumura, Hideo, Horres, Ralf, Terauchi, Ryohei, Rotter, Björn, Udupa, Sripada M., Baum, Michael, Kahl, Günter, Winter, Peter, Bellarmino, Luis, Besser, Bert, Molina, Carlos   +10 more
core   +1 more source

Integration of Green and Far-Red Light with Red-Blue Light Enhances Shoot Multiplication in Micropropagated Strawberry

Horticulturae
Light spectral composition critically regulates plant morphogenesis and molecular adaptation in controlled environments. This study investigated the synergistic effects of three light spectra, red-blue (RB, 7:3), red-blue-green (RGB, 7:3:1), and red-blue-
Yali Li, Ping Huang, Xia Qiu, Feiyu Zhu, Hongwen Chen, Si Wang, Jiaxian He, Yadan Pang, Hui Ma, Fang Wang   +9 more
doaj   +1 more source