A human glomerular SAGE transcriptome database [PDF]
, 2009 Background: To facilitate in the identification of gene products important in regulating renal glomerular structure and function, we have produced an annotated transcriptome database for normal human glomeruli using the SAGE approach.
Kulak, Stephen C. +14 more
core +2 more sources
ENHANCING GENE EXPRESSION PREDICTION IN MAJOR PSYCHIATRIC DISORDERS VIA CO-EXPRESSION MODELS
, 2023 Imputed gene expression based on common variants is instrumental to understanding the biology of psychiatric risk. By identifying trans-eQTLs via co-expression across different brain regions, we aimed to generate a platform for Transcriptome-Wide ...
Rampino, Antonio +12 more
core +1 more source
Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy
Neurobiology of Disease, 2006 The biology underlying epileptic brain activity in humans is not well understood and likely depends on changes in gene expression. We performed a microarray transcriptome profiling of 12 anterolateral temporal cortical samples originating from five ...
Dominique Arion +9 more
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Mating system variation drives rapid evolution of the female transcriptome in Drosophila pseudoobscura [PDF]
, 2014 This research was part funded by the Natural Environment Research Council, Grant Number: NE/I014632/1. The APC was paid through RCUK open access block grant funds.Interactions between the sexes are believed to be a potent source of selection on sex ...
Snook, Rhonda R. +11 more
core +1 more source
Improving gene set enrichment analysis (GSEA) by using regulation directionality
Microbiology SpectrumTo infer the biological meaning from transcriptome data, it is useful to focus on genes that are regulated by the same regulator, i.e., regulons. Unfortunately, current gene set enrichment analysis (GSEA) tools do not consider whether a gene is activated
Biwen Wang +4 more
doaj +1 more source
Predicting chemotherapy response using a variational autoencoder approach
BMC Bioinformatics, 2021 Background Multiple studies have shown the utility of transcriptome-wide RNA-seq profiles as features for machine learning-based prediction of response to chemotherapy in cancer.
Qi Wei, Stephen A. Ramsey
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
TLM-Quant : an open-source pipeline for visualization and quantification of gene expression heterogeneity in growing microbial cells [PDF]
, 2013 Gene expression heterogeneity is a key driver for microbial adaptation to fluctuating environmental conditions, cell differentiation and the evolution of species. This phenomenon has therefore enormous implications, not only for life in general, but also
Piersma, Sjouke +25 more
core +2 more sources
CoxFormer enables spatial omics inference with multimodal generative modeling
Nature CommunicationsGene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution.
Yiyang Yang +8 more
doaj +1 more source