Results 21 to 30 of about 3,806,554 (268)

Construction of Pará rubber tree genome and multi-transcriptome database accelerates rubber researches

BMC Genomics, 2018
Background Natural rubber is an economically important material. Currently the Pará rubber tree, Hevea brasiliensis is the main commercial source. Little is known about rubber biosynthesis at the molecular level.
Yuko Makita, Mika Kawashima, Nyok Sean Lau, Ahmad Sofiman Othman, Minami Matsui   +4 more
doaj   +1 more source

HpeNet: Co-expression Network Database for de novo Transcriptome Assembly of Paeonia lactiflora Pall

Frontiers in Genetics, 2020
The herbaceous peony (Paeonia lactiflora Pall.) is a well-known ornamental flowering and pharmaceutical plant found in China. Its high medicinal value has long been recognized by traditional Chinese medicine (as Radix paeoniae Alba and Radix paeoniae ...
Minghao Sheng, Minghao Sheng, Jiajie She, Wenying Xu, Yan Hong, Zhen Su, Xiaodong Zhang   +6 more
doaj   +1 more source

GeneSurfer enables transcriptome-wide exploration and annotation of gene co-expression modules in 3D spatial transcriptomics data

iScience
Summary: Gene co-expression provides crucial insights into biological functions, however, there is a lack of exploratory analysis tools for localized gene co-expression in large-scale datasets.
Chang Li, Julian Thijssen, Thomas Kroes, Ximaine van der Burg, Louise van der Weerd, Thomas Höllt, Boudewijn Lelieveldt   +6 more
doaj   +1 more source

Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy

Neurobiology of Disease, 2006
The biology underlying epileptic brain activity in humans is not well understood and likely depends on changes in gene expression. We performed a microarray transcriptome profiling of 12 anterolateral temporal cortical samples originating from five ...
Dominique Arion, Michael Sabatini, Travis Unger, Jesús Pastor, Lidia Alonso-Nanclares, Inmaculada Ballesteros-Yáñez, Rafael García Sola, Alberto Muñoz, Károly Mirnics, Javier DeFelipe   +9 more
doaj   +1 more source

MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies.

PLoS Genetics, 2021
Traditional predictive models for transcriptome-wide association studies (TWAS) consider only single nucleotide polymorphisms (SNPs) local to genes of interest and perform parameter shrinkage with a regularization process.
Arjun Bhattacharya, Yun Li, Michael I Love   +2 more
doaj   +1 more source

Predicting chemotherapy response using a variational autoencoder approach

BMC Bioinformatics, 2021
Background Multiple studies have shown the utility of transcriptome-wide RNA-seq profiles as features for machine learning-based prediction of response to chemotherapy in cancer.
Qi Wei, Stephen A. Ramsey
doaj   +1 more source

Using transcriptome Shannon entropy to evaluate the off-target effects and safety of insecticidal siRNAs

Journal of Integrative Agriculture, 2022
A recent breakthrough in agricultural biotechnology is the introduction of RNAi-mediated strategies in pest control. However, the off-target effects of RNAi pest control are still not fully understood.
Wei-hua MA, Tong WU, Zan ZHANG, Hang LI, Gong-ming SITU, Chuan-lin YIN, Xin-hai YE, Meng-yao CHEN, Xian-xin ZHAO, Kang HE, Fei LI   +10 more
doaj   +1 more source

Improving gene set enrichment analysis (GSEA) by using regulation directionality

Microbiology Spectrum
To infer the biological meaning from transcriptome data, it is useful to focus on genes that are regulated by the same regulator, i.e., regulons. Unfortunately, current gene set enrichment analysis (GSEA) tools do not consider whether a gene is activated
Biwen Wang, Frans van der Kloet, Mariah B. M. J. Kes, Joen Luirink, Leendert W. Hamoen   +4 more
doaj   +1 more source

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

Molecular Neurodegeneration, 2020
Background Tau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically examined both the transcriptome and ...
Carl Grant Mangleburg, Timothy Wu, Hari K. Yalamanchili, Caiwei Guo, Yi-Chen Hsieh, Duc M. Duong, Eric B. Dammer, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu, Joshua M. Shulman   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source