Results 91 to 100 of about 213,758 (264)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Detection of Spatially Variable Genes: A Benchmark Study [PDF]
openIn recent years, the field of OMICS sciences has undergone significant advancements due to the emergence of technologies capable of capturing biological data with higher precision.
FERLIN, VALERIA
core
Integrative-Transcriptomics/DamageProfiler untagged-186ff76aa198a0ab37a7
, 2019 A Java based tool to determine damage patterns on ancient DNA as a replacement for ...
Judith Neukamm, Alexander Peltzer
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
Nature Communications, 2019 Long term estrogen deprivation can result in apoptosis in breast cancer cells. Here, the authors show that this apoptosis is induced by the long-range chromatin interaction of loci containing the ESR1 and FOXO 3 genes, resulting in FOXO 3-mediated ...
Mohamed Osama Ali Abdalla +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases
Frontiers in Immunology, 2019 The nuclear factor of activated T cells (NFAT5), also known as a tonicity-responsive enhancer-binding protein, was originally identified as a key transcription factor involved in maintaining cellular homeostasis against hypertonic and hyperosmotic ...
Naeun Lee +5 more
doaj +1 more source
Visualizing post genomics data-sets on customized pathway maps by ProMeTra – aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example [PDF]
, 2009 Neuweger H, Persicke M, Albaum S, et al. Visualizing post genomics data-sets on customized pathway maps by ProMeTra – aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example. BMC Systems Biology.
Hüser, Andrea T. +9 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Fungal genomics and transcriptomics
, 2017 The advent of whole-genome sequencing has resulted in a range of platforms for large-scale analysis of the DNA (genomics), RNA (transcriptomics), protein (proteomics), and metabolite (metabolomics) content of cells.
Carol A. Munro, Duncan Wilson
core +1 more source