Results 141 to 150 of about 320,395 (368)

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

HIV-Tocky system to visualize proviral expression dynamics

Communications Biology
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host and virus-mediated killing.
Omnia Reda, Kazuaki Monde, Kenji Sugata, Akhinur Rahman, Wajihah Sakhor, Samiul Alam Rajib, Sharmin Nahar Sithi, Benjy Jek Yang Tan, Koki Niimura, Chihiro Motozono, Kenji Maeda, Masahiro Ono, Hiroaki Takeuchi, Yorifumi Satou   +13 more
doaj   +1 more source

Standards and infrastructure for managing experimental metadata [PDF]

, 2009
*See also the "related presentation":http://precedings.nature.com/documents/3145/version/1* We present an infrastructure that leverages synergistic reporting standards and ontologies^1,2,3,4,5^ to create a common structured ...
Chris Taylor, Eamonn Maguire, Manon Delahaye, Marco Brandizi, Nataliya Sklyar, Philippe Rocca-Serra, Richard Evans, Susanna-Assunta Sansone   +7 more
core   +2 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Time-shifted expression of acetoclastic and methylotrophic methanogenesis by a single Methanosarcina genomospecies predominates the methanogen dynamics in Philippine rice field soil

Microbiome
Background The final step in the anaerobic decomposition of biopolymers is methanogenesis. Rice field soils are a major anthropogenic source of methane, with straw commonly used as a fertilizer in rice farming.
Xin Li, Qicheng Bei, Mehrdad Rabiei Nematabad, Jingjing Peng, Werner Liesack   +4 more
doaj   +1 more source

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Nature Immunology, 2019
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts
Fan Zhang, Kevin Wei, Kamil Slowikowski, C. Fonseka, Deepak A. Rao, S. Kelly, S. Goodman, Darren Tabechian, L. Hughes, K. Salomon-Escoto, G. Watts, W. Apruzzese, David J. Lieb, D. Boyle, A. Mandelin, B. Boyce, E. Dicarlo, E. Gravallese, P. Gregersen, L. Moreland, G. Firestein, N. Hacohen, C. Nusbaum, J. Lederer, H. Perlman, C. Pitzalis, A. Filer, V. Holers, V. Bykerk, L. Donlin, J. Anolik, M. Brenner, S. Raychaudhuri   +32 more
semanticscholar   +1 more source

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Nature Neuroscience, 2020
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades.
C. Nagy, Malosree Maitra, A. Tanti, M. Suderman, J. Théroux, M. Davoli, K. Perlman, V. Yerko, Y. C. Wang, S. Tripathy, P. Pavlidis, N. Mechawar, J. Ragoussis, G. Turecki   +13 more
semanticscholar   +1 more source

Intriguing symmetry in statistical structures of Siberian larch transcriptome [PDF]

arXiv, 2016
The paper presents a novel approach to infer a structuredness in a set of symbol sequences such as transcriptome nucleotide sequences. A distribution pattern of triplet frequencies in the Siberian larch (\textit{Larix sibirica}~Ledeb.) transcriptome sequences was investigated in the presented study.
arxiv  

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. [PDF]

, 2019
Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy.
Doh, Hanna, Kessenbrock, Kai, Roose, Jeroen P, Samocha, Alexandr   +3 more
core   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source