Results 211 to 220 of about 258,714 (355)

Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

Advanced Materials, EarlyView.
This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar, Kanishka Fernando, Fathima Farzana Kuthubudeen, Gillian Ng, Chor Yong Tay, Narayanan Gopalakrishna Iyer, Chin‐Ann Johnny Ong, Eliza Li Shan Fong   +16 more
wiley   +1 more source

MUSTANG: Multi-sample spatial transcriptomics data analysis with cross-sample transcriptional similarity guidance

Patterns
Summary: Spatially resolved transcriptomics has revolutionized genome-scale transcriptomic profiling by providing high-resolution characterization of transcriptional patterns.
Seyednami Niyakan, Jianting Sheng, Yuliang Cao, Xiang Zhang, Zhan Xu, Ling Wu, Stephen T.C. Wong, Xiaoning Qian   +7 more
doaj  

Combining spatial transcriptomics with tissue morphology. [PDF]

Nat Commun
Chelebian E, Avenel C, Wählby C.
europepmc   +1 more source

Editorial: Forest genomics and biotechnology [PDF]

, 2019
Allona, Isabel, Boerjan, Wout, Kirst, Matias, Sederoff, Ronald, Strauss, Steven   +4 more
core   +1 more source

Integrated metabolomic and transcriptomic analyses of high-tryptophan rice expressing a mutant anthranilate synthase alpha subunit [PDF]

, 2007
Joseph G. Dubouzet, Atsushi Ishihara, Fumio Matsuda, Hisashi Miyagawa, Hiroshi Iwata, K. Wakasa   +5 more
openalex   +1 more source

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Multi-omics insights into biomarkers of breast cancer associated diabetes: a computational approach. [PDF]

Front Med (Lausanne)
Loganathan T, Doss CGP.
europepmc   +1 more source

New Perspectives on Host-Parasite Interplay by Comparative Transcriptomic and Proteomic Analyses of Schistosoma japonicum

, 2006
Feng Liu, Jiong Lu, Wei Hu, Shengyue Wang, Shu‐Jian Cui, Ming Chi, Qing Yan, Xinrong Wang, Huai‐Dong Song, Xue-Nian Xu, Ju-jun Wang, Xianglin Zhang, Xin Zhang, Zhiqin Wang, Chun-liang Xue, Paul J. Brindley, Donald P. McManus, Pengyuan Yang, Zheng Feng, Zhu Chen, Ze‐Guang Han   +20 more
openalex   +2 more sources

Transcript Identification Using Arrayed Hydrogels With TrapFISH

Advanced Materials Technologies, EarlyView.
TrapFISH is a novel method for high‐throughput single‐cell transcriptomics. It embeds cells in hyaluronic acid hydrogel beads and uses probe hybridization to quantify custom gene panels. By arraying hydrogels in microfluidic devices, cell barcoding is removed, enhancing scalability for studying cellular heterogeneity and rare cell states by targeting ...
David B. Morse, Zenon Toprakcioglu, Akhila Denduluri‐Marthi, James D. Brenton, Craig J. Thomas, Tuomas P. J. Knowles   +5 more
wiley   +1 more source

Spatial transcriptomics herald a new era of transcriptome research

Clinical and Translational Medicine, 2023
Dominik Saul, Robyn Laura Kosinsky
openaire   +3 more sources