Results 211 to 220 of about 299,908 (313)

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation. [PDF]

Eur J Immunol
Dobbertin T, Schirmer L.
europepmc   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Single-cell transcriptomic and clonotypic characterization of Waldenström macroglobulinemia reveals intra-patient monoclonal diversity with distinct differentiation states [PDF]

Minghao Dang, Sherif Seif, Maria Acevedo-Calado, Linghua Wang, Joseph P. Sanchez, Lorenzo Gensini, Hima Bansal, Melody Becnel, Mahmoud Gaballa, Hans C. Lee, Oren Pasvolsky, Krina K. Patel, Donna Weber, Jing Christine Ye, Robert Z. Orlowski, Sheeba K. Thomas   +15 more
openalex   +1 more source

Transcriptomics- and Metabolomics-Based Analysis of Key Biological Pathways and Core Genes Involved in the Inhibition Of <i>proteus Mirabilis</i> Biofilm Formation by Protocatechuic Acid

, 2023
Chang Gao, Lu Tian, Jiaxing Lu, Guoli Gong   +3 more
openalex   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Itaconate-Related Gene Signatures as Prognostic Markers in Colon Cancer: Insights From Transcriptomic and Spatial Analysis. [PDF]

Hum Mutat
Zhang T, Meng J, Wang Q, Zhang P, Li H, Wei H, Chen D, Bai C, Nair S.   +8 more
europepmc   +1 more source

Transcriptomic Insights into the Molecular Mechanisms of Indole Analogues from the Periplaneta americana Extract and Their Therapeutic Effects on Ulcerative Colitis

Yuchen Xie, Yu Qi, Shun Yao, Rui Peng, Jing Li   +4 more
openalex   +1 more source

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

, 2013
Ty M. Thomson, Alain Sewer, Florian Martin, Vincenzo Belcastro, Brian P. Frushour, Stephan Gebel, Jennifer Park, Walter K. Schlage, Marja Talikka, Dmitry M. Vasilyev, Jurjen W. Westra, Julia Hoeng, Manuel C. Peitsch   +12 more
openalex   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

The co-location of MARCO + macrophages and SPOCK1 + fibroblasts contributes to the poor prognosis and undesirable immunotherapy response in colorectal cancer. [PDF]

BMC Cancer
Pan Y, Ying H, Luo M, Xuan Q.
europepmc   +1 more source