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Nature CommunicationsTransdermal drug delivery has been regarded as an alternative to oral delivery and subcutaneous injection. However, needleless transdermal delivery of biomacromolecules remains a challenge.
Wenjun Zhu +11 more
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Transdermal drug delivery [PDF]
Nature Biotechnology, 2008 Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation
M. Prausnitz, R. Langer
semanticscholar +4 more sources
Scientia Pharmaceutica, 2019 Nanoemulsions (NEs) are colloidal dispersions of two immiscible liquids, oil and water, in which one is dispersed in the other with the aid of a surfactant/co-surfactant mixture, either forming oil-in-water (o/w) or water-in-oil (w/o) nanodroplets ...
Dalia S. Shaker +3 more
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Recent Advancement of Medical Patch for Transdermal Drug Delivery
Medicina, 2023 Transdermal patches are a non-invasive method of drug administration. It is an adhesive patch designed to deliver a specific dose of medication through the skin and into the bloodstream throughout the body.
W. Wong +3 more
semanticscholar +1 more source
Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals
Pharmaceutics, 2023 Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate ...
Hiep X. Nguyen, C. Nguyen
semanticscholar +1 more source
Functional nano-systems for transdermal drug delivery and skin therapy
Nanoscale Advances, 2023 Transdermal drug delivery is one of the least intrusive and patient-friendly ways for therapeutic agent administration. Recently, functional nano-systems have been demonstrated as one of the most promising strategies to treat skin diseases by improving ...
Lijun Liu +14 more
semanticscholar +1 more source
Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules
Microsystems & Nanoengineering, 2023 COVID-19 has seriously threatened public health, and transdermal vaccination is an effective way to prevent pathogen infection. Microneedles (MNs) can damage the stratum corneum to allow passive diffusion of vaccine macromolecules, but the delivery ...
Ying Zheng +8 more
semanticscholar +1 more source
Enhancement strategies for transdermal drug delivery systems: current trends and applications
Drug Delivery and Translational Research, 2021 Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market.
Delly Ramadon +3 more
semanticscholar +1 more source
Recent advances in transdermal drug delivery systems: a review
Biomaterials Research, 2021 Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease ...
Woo Yeup Jeong +3 more
semanticscholar +1 more source
Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release
Pharmaceutics, 2023 In this work, we aim to address several strategies to improve transdermal drug delivery, such as iontophoresis, sonophoresis, electroporation and micron. We also propose a review of some transdermal patches and their applications in medicine.
Olimpia Dumitriu Buzia +6 more
semanticscholar +1 more source