Results 21 to 30 of about 55,857 (266)

Preparation and In Vitro Characterization of Microneedles Containing Inclusion Complexes Loaded with Progesterone

open access: yesPharmaceutics, 2023
Objective: In order to improve patient compliance and the ease of use during progesterone application, and to increase the clinical application of progesterone, progesterone was made into a microneedle. Methods: Progesterone complexes were prepared using
Hongji He   +6 more
doaj   +1 more source

Optimization of Influential Variables in the Development of Buprenorphine and Bupivacaine Loaded Invasome for Dermal Delivery [PDF]

open access: yesAdvanced Pharmaceutical Bulletin, 2021
Purpose: Hydrophilic drugs are extensively applied in clinical applications. Inadequate dermal penetration of these drugs is a great challenge. Incorporation of drugs into nano-carrier systems overcomes lower penetration drawbacks.
Soraya Babaie   +5 more
doaj   +1 more source

The Transdermal Delivery of Therapeutic Cannabinoids

open access: yesPharmaceutics, 2022
Recently, several studies have indicated an increased interest in the scientific community regarding the application of Cannabis sativa plants, and their extracts, for medicinal purposes.
Haleh Mahmoudinoodezh   +5 more
doaj   +1 more source

Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology

open access: yesMolecules, 2017
Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it ...
Tyler Pentek   +3 more
doaj   +1 more source

Physiologically-based pharmacokinetic simulations in pharmacotherapy: selection of the optimal administration route for exogenous melatonin

open access: yesADMET and DMPK, 2019
The benefits of melatonin on human body are drawing increasing attention from several researchers in different fields. While its role as cure for sleep disturbances (e.g., jet lag, insomnia) is well documented and established, new functions in ...
Adriana Savoca, Davide Manca
doaj   +1 more source

Design, Development, and Evaluation of Treprostinil Embedded Adhesive Transdermal Patch

open access: yesPharmaceutics, 2023
Clinical application of treprostinil in pulmonary arterial hypertension is hampered by adverse effects caused by its high dosing frequency. The objective of this investigation was to Formulate an adhesive-type transdermal patch of treprostinil and ...
Ibrahim Alissa   +7 more
doaj   +1 more source

Angiotensin-Neprilysin Inhibitor Therapy: A Retrospective Chart Study

open access: yesINNOVATIONS in Pharmacy
Background: Guideline-directed medical therapy in patients with systolic heart failure (HF) has demonstrated improvement in morbidity and mortality rates.
Roda Plakogiannis   +3 more
doaj   +1 more source

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

open access: yesScientia Pharmaceutica, 2020
Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs.
Daniélle van Staden   +2 more
doaj   +1 more source

Transdermal buprenorphine for pain management in children

open access: yesDrugs in Context, 2021
Pain is one of the main symptoms reported by sick children, particularly by those suffering from cancer. Opioids are very useful in controlling this symptom but they are burdened with significant side effects that limit their use in children ...
Giorgio Attinà   +5 more
doaj   +1 more source

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

open access: yesPharmaceutics, 2015
Novel polyethylene oxide (PEO) hydrogel films were synthesized via UV crosslinking with varying concentrations of pentaerythritol tetra-acrylate (PETRA) as crosslinking agent.
Rachel Shet Hui Wong   +2 more
doaj   +1 more source

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