Results 41 to 50 of about 92,575 (360)

Ion-Pair Compounds of Strychnine for Enhancing Skin Permeability: Influencing the Transdermal Processes In Vitro Based on Molecular Simulation

open access: yesPharmaceuticals, 2021
This research aimed to explore how Strychnine (Str) ion-pair compounds affect the in vitro transdermal process. In order to prevent the influence of different functional groups on skin permeation, seven homologous fatty acids were selected to form ion ...
Lili He   +7 more
doaj   +1 more source

Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

open access: yesJournal of Clinical Medicine, 2021
Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target ...
Vahid Alimardani   +6 more
semanticscholar   +1 more source

Transdermal Delivery Systems for Biomolecules

open access: yesJournal of Pharmaceutical Innovation, 2021
Purpose The present review article focuses on highlighting the main technologies used as tools that improve the delivery of transdermal biomolecules, addressing them from the point of view of research in the development of transdermal systems that use ...
Ma. Concepción Peña-Juárez   +2 more
semanticscholar   +1 more source

Formulation and Evaluation of Niosomal Alendronate Sodium Encapsulated in Polymeric Microneedles: In Vitro Studies, Stability Study and Cytotoxicity Study

open access: yesNanomaterials, 2022
The aim of this study is to design and evaluate a transdermal delivery system for alendronate sodium (ALS) loaded with nanocarrier to improve its permeability and prolong its release.
Ahlam Zaid Alkilani   +5 more
doaj   +1 more source

Transdermal Delivery of Proteins [PDF]

open access: yesAAPS PharmSciTech, 2011
Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows
Ajay K. Banga, Haripriya Kalluri
openaire   +2 more sources

Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride

open access: yesInternational Journal of Nanomedicine, 2021
Marianne Joseph Naguib,1 Ibrahim Elsayed,1,2 Mahmoud Hassan Teaima1 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2Department of Pharmaceutical Sciences, College of Pharmacy and Thumbay ...
Naguib MJ, Elsayed I, Teaima MH
doaj  

Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations

open access: yesScientia Pharmaceutica, 2022
Oils, including essential oils and their constituents, are widely reported to have penetration enhancement activity and have been incorporated into a wide range of pharmaceutical formulations.
Bahjat Alhasso   +2 more
doaj   +1 more source

Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review

open access: yesCosmetics, 2021
Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach is to use lipid nanoparticles as they not only facilitate penetration across skin but also avoid the drawbacks of ...
D. Khater   +7 more
semanticscholar   +1 more source

Preparation and In Vitro Characterization of Microneedles Containing Inclusion Complexes Loaded with Progesterone

open access: yesPharmaceutics, 2023
Objective: In order to improve patient compliance and the ease of use during progesterone application, and to increase the clinical application of progesterone, progesterone was made into a microneedle. Methods: Progesterone complexes were prepared using
Hongji He   +6 more
doaj   +1 more source

Physiologically-based pharmacokinetic simulations in pharmacotherapy: selection of the optimal administration route for exogenous melatonin

open access: yesADMET and DMPK, 2019
The benefits of melatonin on human body are drawing increasing attention from several researchers in different fields. While its role as cure for sleep disturbances (e.g., jet lag, insomnia) is well documented and established, new functions in ...
Adriana Savoca, Davide Manca
doaj   +1 more source

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