Results 51 to 60 of about 55,857 (266)

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

A Comprehensive Review of the Evolution of Insulin Development and Its Delivery Method

Pharmaceutics, 2022
The year 2021 marks the 100th anniversary of the momentous discovery of insulin. Through years of research and discovery, insulin has evolved from poorly defined crude extracts of animal pancreas to recombinant human insulin and analogues that can be ...
Vaisnevee Sugumar, Kuan Ping Ang, Ahmed F. Alshanon, Gautam Sethi, Phelim Voon Chen Yong, Chung Yeng Looi, Won Fen Wong   +6 more
doaj   +1 more source

Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion

, 2011
Yong-Tai Zhang, Ji-Hui Zhao, Su-Juan Zhang, Yang-Zi Zhong, Zhi Wang, Ying Liu, Feng Shi, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaObjective: The purpose of this ...
Zhao JH, Liu Y, Feng NP, Zhong YT, Shi F, Wang Z, Zhang SJ, Zhong YZ, Nianping Feng   +8 more
core   +1 more source

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

Transdermal wires for improved integration in vivo [PDF]

, 2023
Alternative engineering approaches have led the design of implants with controlled physical features to minimize adverse effects in biological tissues. Similar efforts have focused on optimizing the design features of percutaneous VAD drivelines with the
Cesarovic, Nikola, Kourouklis, Andreas P, Volkmar Falk, Edoardo Mazza, Chanfon, Astrid, Xi Wu, Falk, Volkmar, Baños, Miguel, Andreas P. Kourouklis, Ferrari, Aldo, Aldo Ferrari, Julius Kaemmel, Simone de Brot, Mazza, Edoardo, Miguel Baños, Kaemmel, Julius, De Brot, Simone, Astrid Chanfon, Wu, Xi, Nikola Cesarovic   +19 more
core   +1 more source

Chiral Microneedle Arrays With Terahertz Chiroptical Activity With Chiral‐Plasmon‐Chiral‐Phonon Resonance

Advanced Materials, EarlyView.
ABSTRACT Microneedle arrays (MNAs) is a rapidly emerging technology with broad biomedical applications in drug delivery and biosensing. With sub‐millimeter dimensions and periodicity, MNAs possess geometries nearly ideal for biomedical devices operating within the terahertz (THz) spectral window.
Sang Hyun Lee, Hong Ju Jung, John Kim, Bum Chul Park, Caio V. C. R. da Silva, André F. de Moura, Nicholas A. Kotov   +6 more
wiley   +1 more source

High‐Performance Transparent, Deformable, and Recoverable Biomimetic Stevia–PVA Hydrogel Triboelectric Nanogenerator with Machine Learning‐Assisted Motion Recognition

Advanced Materials, EarlyView.
A transparent, deformable stevia–PVA hydrogel triboelectric nanogenerator delivers significantly enhanced mechanical strength and electrical output through biomimetic hydrogen‐bonded networks. Coupled with machine learning–assisted signal recognition, the self‐powered hydrogel enables accurate human‐motion sensing for intelligent wearable and IoT ...
Thien Trung Luu, Bui Minh Quang, Toan Minh Pham, Jinsoo Kim, Kyungwho Choi, Dukhyun Choi   +5 more
wiley   +1 more source

Microneedle-Assisted Percutaneous Delivery of Paeoniflorin-Loaded Ethosomes

Molecules, 2018
Paeoniflorin, the main component of total glucosides of paeony (TGP), shows good therapeutic effects in arthritis, but has low bioavailability when administered orally.
Yahua Cui, Yujia Mo, Qi Zhang, Wanwan Tian, Yutao Xue, Jie Bai, Shouying Du   +6 more
doaj   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

A Transdermal Drug Delivery System Containing Deferioxamine Mesylate for the Treatment of Beta-Thalassaemia Major

, 2012
Patients with beta-thalassaemia major need blood transfusion frequently during their whole life. However, frequent transfusions will eventually lead to the accumulation of trivalent iron, resulting in iron overload.
謝錦雄;楊台鴻;黃義侑, Hsieh, Chin-Hsiung; Ku, Yuan-An; Chiu, Lien-Hua; Young, Tai-Horng; Huang, Yi-You   +1 more
core   +1 more source