Results 11 to 20 of about 1,640,128 (340)

Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

Microsystems & Nanoengineering, 2023
COVID-19 has seriously threatened public health, and transdermal vaccination is an effective way to prevent pathogen infection. Microneedles (MNs) can damage the stratum corneum to allow passive diffusion of vaccine macromolecules, but the delivery ...
Ying Zheng, Rui Ye, Xia Gong, Jingbo Yang, Bin Liu, Yunsheng Xu, Gang Nie, Xi Xie, Lelun Jiang   +8 more
doaj   +2 more sources

Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines

Nature Communications
Transdermal drug delivery has been regarded as an alternative to oral delivery and subcutaneous injection. However, needleless transdermal delivery of biomacromolecules remains a challenge.
Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen, Zhuang Liu   +11 more
doaj   +2 more sources

Plant Exosome-like Nanoparticles as Biological Shuttles for Transdermal Drug Delivery

Bioengineering, 2023
Exosomes act as emerging transdermal drug delivery vehicles with high deformability and excellent permeability, which can be used to deliver various small-molecule drugs and macromolecular drugs and increase the transdermal and dermal retention of drugs,
Ye Wang, Yongsheng Wei, Hui Liao, Hongwei Fu, Xiaobin Yang, Qi Xiang, Shu Zhang   +6 more
doaj   +2 more sources

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Frontiers in Bioengineering and Biotechnology, 2021
The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications.
Yi-Qun Yu, Yi-Qun Yu, Xue Yang, Xiao-Fang Wu, Yi-Bin Fan   +4 more
doaj   +2 more sources

Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis

Drug Delivery, 2023
Methotrexate (MTX) is a first-line treatment for rheumatoid arthritis (RA), but its clinical use is greatly limited by the adverse effects and poor patient compliance caused by traditional oral administration or injection.
Weiman Zhao, Lijie Zheng, Jianhui Yang, Zihui Ma, Xinyi Tao, Qingqing Wang   +5 more
doaj   +2 more sources

Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities

Pharmaceutics, 2021
Chemotherapeutic drugs are primarily administered to cancer patients via oral or parenteral routes. The use of transdermal drug delivery could potentially be a better alternative to decrease the dose frequency and severity of adverse or toxic effects ...
Rabin Neupane, Sai H. S. Boddu, Mariam Sami Abou-Dahech, Rinda Devi Bachu, David Terrero, R. Jayachandra Babu, Amit K. Tiwari   +6 more
doaj   +2 more sources

Breaking boundaries: the advancements in transdermal delivery of antibiotics

Drug Delivery
Transdermal drug delivery systems (TDDS) for antibiotics have seen significant advances in recent years that aimed to improve the efficacy and safety of these drugs.
Ahlam Zaid Alkilani, Rania Hamed, Batool Musleh, Zaina Sharaire   +3 more
doaj   +2 more sources

Nanofiber as a novel vehicle for transdermal delivery of therapeutic agents: challenges and opportunities

Future Journal of Pharmaceutical Sciences, 2021
Background Transdermal delivery of drugs is a quite challenging task for pharmaceutical scientists. The transdermal route is preferred over the oral route due to various advantages like avoidance of the first-pass effect, non-invasiveness, and high ...
Lalit Kumar, Shivani Verma, Kajal Joshi, Puneet Utreja, Sumit Sharma   +4 more
doaj   +2 more sources

Recent Development of Nanomaterials for Transdermal Drug Delivery

Biomedicines, 2023
Nano-engineered medical products first appeared in the last decade. The current research in this area focuses on developing safe drugs with minimal adverse effects associated with the pharmacologically active cargo.
Moong Yan Leong, Yeo Lee Kong, Kevin Burgess, Won Fen Wong, Gautam Sethi, Chung Yeng Looi   +5 more
doaj   +2 more sources

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Pharmaceutics, 2023
Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate ...
Hiep X. Nguyen, C. Nguyen
semanticscholar   +1 more source