Results 21 to 30 of about 23,147 (265)

Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents

Drug Delivery, 2017
Topical and transdermal drug delivery has great potential in non-invasive and non-oral administration of poorly bioavailable therapeutic agents. However, due to the barrier function of the stratum corneum, the drugs that can be clinically feasible ...
Ki-Taek Kim, Joon Lee, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, Joo-Hyun Song, Minwoong Jung, Myoung-Hoon Jang, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim   +10 more
doaj   +1 more source

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

Scientia Pharmaceutica, 2020
Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs.
Daniélle van Staden, Jeanetta du Plessis, Joe Viljoen   +2 more
doaj   +1 more source

Plant Exosome-like Nanoparticles as Biological Shuttles for Transdermal Drug Delivery

Bioengineering, 2023
Exosomes act as emerging transdermal drug delivery vehicles with high deformability and excellent permeability, which can be used to deliver various small-molecule drugs and macromolecular drugs and increase the transdermal and dermal retention of drugs,
Ye Wang, Yongsheng Wei, Hui Liao, Hongwei Fu, Xiaobin Yang, Qi Xiang, Shu Zhang   +6 more
doaj   +1 more source

Novel chemical permeation enhancers for transdermal drug delivery

Asian Journal of Pharmaceutical Sciences, 2014
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effect, easy use and better patient compliance.
Yang Chen, Peng Quan, Xiaochang Liu, Manli Wang, Liang Fang   +4 more
doaj   +1 more source

Delivery of Insulin via Skin Route for the Management of Diabetes Mellitus: Approaches for Breaching the Obstacles

Pharmaceutics, 2021
Insulin is used for the treatment of diabetes mellitus, which is characterized by hyperglycemia. Subcutaneous injections are the standard mode of delivery for insulin therapy; however, this procedure is very often invasive, which hinders patient ...
Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi   +4 more
doaj   +1 more source

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Frontiers in Bioengineering and Biotechnology, 2021
The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications.
Yi-Qun Yu, Yi-Qun Yu, Xue Yang, Xiao-Fang Wu, Yi-Bin Fan   +4 more
doaj   +1 more source

Transdermal Delivery of Proteins [PDF]

AAPS PharmSciTech, 2011
Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows
Haripriya, Kalluri, Ajay K, Banga
openaire   +2 more sources

Nanofiber as a novel vehicle for transdermal delivery of therapeutic agents: challenges and opportunities

Future Journal of Pharmaceutical Sciences, 2021
Background Transdermal delivery of drugs is a quite challenging task for pharmaceutical scientists. The transdermal route is preferred over the oral route due to various advantages like avoidance of the first-pass effect, non-invasiveness, and high ...
Lalit Kumar, Shivani Verma, Kajal Joshi, Puneet Utreja, Sumit Sharma   +4 more
doaj   +1 more source

Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis

Drug Delivery, 2023
Methotrexate (MTX) is a first-line treatment for rheumatoid arthritis (RA), but its clinical use is greatly limited by the adverse effects and poor patient compliance caused by traditional oral administration or injection.
Weiman Zhao, Lijie Zheng, Jianhui Yang, Zihui Ma, Xinyi Tao, Qingqing Wang   +5 more
doaj   +1 more source

Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines

Nature Communications
Transdermal drug delivery has been regarded as an alternative to oral delivery and subcutaneous injection. However, needleless transdermal delivery of biomacromolecules remains a challenge.
Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen, Zhuang Liu   +11 more
doaj   +1 more source