Results 141 to 150 of about 145,799 (355)

Circuitry of nuclear factor κB signaling [PDF]

, 2006
Over the past few years, the transcription factor nuclear factor (NF)-κB and the proteins that regulate it have emerged as a signaling system of pre-eminent importance in human physiology and in an increasing number of pathologies. While NF-κB is present
Baltimore, David, Hoffmann, Alexander
core  

573. High-Throughput Screening Identifies Effective Enhancers of Lentiviral Transduction [PDF]

, 2012

openalex   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Role of the PAS2 domain of the NifL regulatory protein in redox signal transduction [PDF]

, 2010
EThOS - Electronic Theses Online ServiceGBUnited ...
Slavny, Peter
core  

Ultrasonography Compared With Computed Tomography in Identifying Thoracic Aortic Aneurysms in Patients With Giant Cell Arteritis

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to evaluate the correlation and agreement between ultrasonography and computed tomography (CT) in measuring ascending aorta diameter in patients with giant cell arteritis (GCA) and to investigate the development of new ascending aortic aneurysms in patients with newly diagnosed GCA.
Anne C. Bull Haaversen, Lene K. Brekke, Tanaz A. Kermani, Øyvind Molberg, Andreas P. Diamantopoulos   +4 more
wiley   +1 more source

Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by EZH2 Inhibition in Colorectal Carcinoma Cells

Biomolecules
Background: The scaffold protein tyrosine kinase substrate 4 (TKS4) undergoes tyrosine phosphorylation by the epidermal growth factor receptor (EGFR) pathway via Src kinase.
Mevan Jacksi, Eva Schad, Agnes Tantos
doaj   +1 more source

A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells [PDF]

, 2016
Atum M. Buo, Mark S. Williams, Jaclyn P. Kerr, Joseph P. Stains   +3 more
openalex   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

The significance of chemical transfection/transduction enhancers in promoting the viral vectors-assisted gene delivery approaches: A focus on potentials for inherited retinal diseases

Electronic Journal of Biotechnology
Viral vectors are among the main approaches currently used in studies for executing gene delivery to target cells. During the past decades of active studies in gene therapy, including viruses, adenoviruses (Ads), lentiviruses (LVs), and adeno-associated ...
Sajad Najafi, Azam Rahimpour, Hamid Ahmadieh, Maryam Maleki Tehrani, Mohammad Amin Khalilzad, Fatemeh Suri, Javad Ranjbari   +6 more
doaj   +1 more source

High‐Entropy Alloy Design Toward Cobalt Substitution for High Hardness and Low Wear Rate Using X–Cr–Fe–Mn–Ni System

Advanced Engineering Materials, EarlyView.
This study explores the replacement of cobalt using the high‐entropy alloy design strategy for wear‐resistant components operating at high temperatures. Starting from the Cantor alloy, cobalt is substituted with Cu, Al, V, or Mo. Metallurgical and tribological analyses reveal that aluminum, vanadium, and molybdenum effectively strengthen the developed ...
Rafaël Jénot, Laurent Peltier, Fodil Meraghni, Mathieu Marquer, Oriane Baulin, Clotilde Macke‐Bart   +5 more
wiley   +1 more source