Results 291 to 300 of about 851,785 (340)

The Template-Jumping Editing Approach in <i>F9</i>-Associated Hemophilia B Gene Therapy. [PDF]

Int J Mol Sci
Sattarov R, Kuznetsov A, Klimko V, Ignatyeva E, Ivanov R, Karabelsky A, Fizikova A.   +6 more
europepmc   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Targeting NADPH oxidase 2 suppresses the growth of esophageal squamous cell carcinoma by regulating BTG2 pathway. [PDF]

Discov Oncol
Liu XJ, Yang CL, Zhang YL, Huang JX.
europepmc   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Integrative Multi-Omics and Functional Characterization Reveal MCM4 as a Key Oncogenic Regulator in Hepatocellular Carcinoma. [PDF]

Onco Targets Ther
Qiu M, Xu L.
europepmc   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression. [PDF]

Biotechnol Bioeng
Mullick A, Morasse A, Leclerc M, Liu Z, Liu QY, Leclerc S, Momcilovic M, Viau A, Kamen AA.   +8 more
europepmc   +1 more source

LncRNA NBR2 affects pancreatic β-cell function in type 2 diabetes mellitus by targeting miR-646. [PDF]

Diabetol Metab Syndr
Pu M, Kong L, Li J, Su L, Chen Y.
europepmc   +1 more source

Successful Delivery of Small Non-Coding RNA Molecules into Human iPSC-Derived Lung Spheroids in 3D Culture Environment. [PDF]

Biomedicines
Schweikert A, De Santi C, Teoh XJ, Xin Yang FL, O'Sullivan E, Greene CM, Hurley K, Oglesby IK.   +7 more
europepmc   +1 more source

Evaluation of rat pancreatic islets damage after siRNA microporation. [PDF]

PLoS One
Tomsovska V, Leontovyc I, Zacharovova K, Fabryova E, Koblas T, Berkova Z, Kriz J.   +6 more
europepmc   +1 more source