Results 331 to 340 of about 968,391 (388)

ALPP Induces Epithelial-Mesenchymal Transition by Activating the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells. [PDF]

Cancer Manag Res
Gao B, Li B, Hu J, Hu X, Su M.
europepmc   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Activation of the coagulation cascade as a mechanism for selective nanoparticle-mediated RNA delivery to the endothelium in vivo. [PDF]

Sci Adv
Guzman EB, Kowalski PS, Langer RS, Anderson DG.   +3 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Maspardin/SPG21 controls lysosome motility and TFEB phosphorylation through RAB7 positioning. [PDF]

J Cell Biol
Jacqmin T, Gilis F, Albert M, Gaussin JF, Jadot M, Boonen M.   +5 more
europepmc   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Towards effective cystic fibrosis gene therapy by optimizing prime editing and pulmonary-targeted LNPs. [PDF]

Front Syst Biol
Lange KS, Wiesner LM, Susat K, Köhler V, Lenger M, Michalek CA, Baack AL, Mundt PF, Kanthak K, Guckes IA, Sanfilippo L, Haverkamp L, Mahajan UA, Zimmer FH, Zimmermann S, Radukic MT, Klages LJ, Kalinowski J, Müller KM.   +18 more
europepmc   +1 more source

Proteomic Identification of ALDOA as a Pathogenic TDP-43 Interaction Partner in ALS. [PDF]

Degener Neurol Neuromuscul Dis
Yan K, Deng J, Yong Y, Bi F.
europepmc   +1 more source

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Cell Transfection

2011
Transfection is a process of introducing nucleic acid into eukaryotic cells using various chemical or physical methods. As a nonviral delivery system, transfection has gained popularity. The cost-effective and rapid production of recombinant human therapeutic proteins in sufficient quantities has been one of the challenges faced in biopharmaceutical ...
Chahal, P., Durocher, Y., Kamen, A.
openaire   +1 more source

Biolistic Transfection

2003
Recent improvements in the biolistic technique and devices have increased its usefulness for transfection of neurons. With these recent advances, both dissociated and slice cultures can be transfected at reasonably high rates. This chapter focuses on the parameters that determine the successful biolistic transfection of neurons in both types of ...
Paul C, Bridgman, Michael E, Brown, Irina, Balan   +2 more
openaire   +2 more sources