Results 71 to 80 of about 12,810,823 (193)
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Sensors, 2020 The instrument transformers scenario is moving towards the adoption of a new generation of low-power instrument transformers. This disruptive change also requires that the modeling, characterization, and testing of those devices must be improved ...
Abbas Ghaderi +3 more
doaj +1 more source
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Spectral analysis of two frequency response of the 1D model in interaction with the function of the transfer of "response-excitation" [PDF]
Zbornik Radova Građevinskog Fakulteta, 2019 In this paper, an excitation with two different frequencies of displacement amplitudes outside the resonant region is imposed on a 1D dynamic model with resistance of the substrate.
Miličić Ilija M. +2 more
doaj
A Matrix Approach for Analyzing Signal Flow Graph
Information, 2020 Mason’s gain formula can grow factorially because of growth in the enumeration of paths in a directed graph. Each of the (n − 2)! permutation of the intermediate vertices includes a path between input and output nodes.
Shyr-Long Jeng +2 more
doaj +1 more source
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Placental structure, function and drug transfer
, 2015 In the late 1950s and early 1960s, the devastating series of thalidomide-induced birth defects raised awareness of the imperfect state of the placenta as a barrier to drug transfer.
Sarah Griffiths, Jeremy P Campbell
semanticscholar +1 more source
Cells, 2019 Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids, RNA, and DNA. They are derived from endocytic membranes and can transfer signals to recipient cells, thus mediating a novel mechanism of cell-to-cell ...
Sangiliyandi Gurunathan +4 more
semanticscholar +1 more source