Results 81 to 90 of about 8,378,733 (308)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Mechanism of nucleate pool boiling heat transfer to sodium and the criterion for stable boiling [PDF]

open access: yes, 1967
A comparison between liquid metals and other common fluids, like water, is made as regards to the various stages of nucleate pool boiling. It is suggested that for liquid metals the stage of building the thermal layer plays the most significant part in ...
Shai, Isaac
core  

Approximate State–Space and Transfer Function Models for 2×2 Linear Hyperbolic Systems with Collocated Boundary Inputs

open access: yesInternational Journal of Applied Mathematics and Computer Science, 2020
Two approximate representations are proposed for distributed parameter systems described by two linear hyperbolic PDEs with two time- and space-dependent state variables and two collocated boundary inputs.
Bartecki Krzysztof
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Control ofa ThermoelectricCooling Module by Metaheuristic Optimization Algorithms

open access: yesHavacılık ve Uzay Teknolojileri Dergisi
In this study, the proportional-integral-derivative (PID) controller of a sample thermoelectric cooler(TEC)system model is optimized using four different metaheuristic optimization algorithms.
Tufan KOÇ, Nevra BAYHAN
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The structure and function of neurons with variable nonlinear transfer function

open access: yes, 2005
One novel neuron with variable nonlinear transfer function is firstly proposed, It could also be called as subsection transfer function neuron. With different transfer function components, by virtue of multi-thresholded, the variable transfer function ...
Wang, SJ, Chinese Acad Sci, Inst Semicond, Lab Artificial Neural Networks, Beijing 100083, Peoples R China.   +2 more
core  

Efficient Multi-Material Volume Rendering for Realistic Visualization with Complex Transfer Functions

open access: yesJournal of Imaging
Physically based realistic direct volume rendering (DVR) is a critical area of research in scientific data visualization. The prevailing realistic DVR methods are primarily rooted in outdated theories of participating media rendering and often lack ...
Chunxiao Xu   +4 more
doaj   +1 more source

Preparation and analysis of testate amoebae in peatland palaeoenvironmental studies [PDF]

open access: yesMires and Peat, 2010
The use of testate amoebae in studies of peatland hydrology and palaeohydrology has been increasing, and considerable efforts have been made over the past decade to standardise techniques as much as possible.
R.K. Booth, M. Lamentowicz, D.J. Charman
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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