Results 81 to 90 of about 16,590,337 (307)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Modeling the Electrical Activity of the Heart via Transfer Functions and Genetic Algorithms

Biomimetics
Although healthcare and medical technology have advanced significantly over the past few decades, heart disease continues to be a major cause of mortality globally. Electrocardiography (ECG) is one of the most widely used tools for the detection of heart
Omar Rodríguez-Abreo, Mayra Cruz-Fernandez, Carlos Fuentes-Silva, Mario A. Quiroz-Juárez, José L. Aragón   +4 more
doaj   +1 more source

Comparative Analysis of Transfer Function Method with Advanced Flood Prediction Techniques [PDF]

Water Harvesting Research
In this paper, the evaluation of the performance of five flood prediction models in the Simineh-Rood River, Lake Urmia basin, Iran, is discussed in detail.
Jafar Chabokpour
doaj   +1 more source

Unstained blood smear contrast enhancement using spectral time multiplexing super resolution

Journal of Spectral Imaging, 2020
We report the use of Time Multiplexing Super Resolution (TMSR) to reduce significantly speckle noise in spectral imaging microscopy of unstained thin blood smear samples of malaria-infected blood.
Marie-Florence A. Yebouet, Ambroise K. Diby, Kenneth A. Kaduki, Jérémie T. Zoueu   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

Cells, 2019
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids, RNA, and DNA. They are derived from endocytic membranes and can transfer signals to recipient cells, thus mediating a novel mechanism of cell-to-cell ...
Sangiliyandi Gurunathan, M. Kang, Muniyandi Jeyaraj, M. Qasim, Jin-Hoi Kim   +4 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Approximate State–Space and Transfer Function Models for 2×2 Linear Hyperbolic Systems with Collocated Boundary Inputs

International Journal of Applied Mathematics and Computer Science, 2020
Two approximate representations are proposed for distributed parameter systems described by two linear hyperbolic PDEs with two time- and space-dependent state variables and two collocated boundary inputs.
Bartecki Krzysztof
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source