Results 161 to 170 of about 100,115 (305)

An Automation Platform for the Chemoenzymatic Synthesis of Complex Sulfated and Branched Glycans. [PDF]

J Am Chem Soc
Chakraborty S, Minder K, Prudden AR, Boons GJ.   +3 more
europepmc   +1 more source

Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity

Angewandte Chemie, EarlyView.
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser, Sarah Heinicke, Sarah E. O'Connor, Maite Colinas   +3 more
wiley   +2 more sources

Mechanisms of insecticide resistance in mosquitoes: A systematic review of biochemical and physiological perspectives for sustainable vector control. [PDF]

Medicine (Baltimore)
Abbasi E.
europepmc   +1 more source

Aminoacyl-tRNA-dependent enzymes in natural product biosynthesis: structure-function insights. [PDF]

J Antibiot (Tokyo)
Zheng Y, Zhao Y, Takahashi S.
europepmc   +1 more source

The influence of glutathione S-transferases M1 and M3 on the development of bladder cancer [PDF]

Problem: Cigarette smoking is the most important risk factor of transitional cell carcinoma of the urinary bladder. The effect of the glutathione S- transferases M1 (GSTM1) and M3 (GSTM3) on the influence of this risk factor was investigated.
Bolt, Hermann M., Golka, Klaus, Schmidt, Tobias, Selinski, Silvia   +3 more
core  

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, EarlyView.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Oxidative stress and cardiovascular risk related to urinary metal(loid) levels in a pediatric population. [PDF]

Environ Geochem Health
Ortega-Romero M, Rojas Lima E, Rubio-Gutiérrez JC, Narváez Morales J, Bravo Carvajal IY, Esparza García M, Mejia MÁ, Tamayo Y Orozco JA, Mendez-Hernández P, Barbier OC, Medeiros M, Aztatzi-Aguilar OG.   +11 more
europepmc   +1 more source

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, EarlyView.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Noncanonical amino acids enable plug and play vaccine platform in the ALiCE cell free system. [PDF]

NPJ Vaccines
Armero-Gimenez J, Schleusner J, Wilbers RHP, Schots A, Spiga L, Tregoning JS, Brown JC, Zhou J, Juergens H, Finnern R, Williams C.   +10 more
europepmc   +1 more source

Mechanistic basis of antimicrobial resistance mediated by the phosphoethanolamine transferase MCR-1. [PDF]

Nat Commun
Zinkle AP, Batista MB, Herrera CM, Erramilli SK, Kloss B, Ashraf KU, Nosol K, Zhang G, Cater RJ, Marty MT, Kossiakoff AA, Trent MS, Nygaard R, Stansfeld PJ, Mancia F.   +14 more
europepmc   +1 more source