Hidden Glutathione Transferases in the Human Genome [PDF]
Biomolecules, 2023 With the development of accurate protein structure prediction algorithms, artificial intelligence (AI) has emerged as a powerful tool in the field of structural biology. AI-based algorithms have been used to analyze large amounts of protein sequence data
Aaron J. Oakley
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Glutathione Transferases as Efficient Ketosteroid Isomerases [PDF]
Frontiers in Molecular Biosciences, 2021 In addition to their well-established role in detoxication, glutathione transferases (GSTs) have other biological functions. We are focusing on the ketosteroid isomerase activity, which appears to contribute to steroid hormone biosynthesis in mammalian ...
Bengt Mannervik +4 more
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Expression Patterns of Drosophila Melanogaster Glutathione Transferases [PDF]
Insects, 2022 Glutathione transferases (GSTs) are ubiquitous enzymes that catalyze the conjugation of glutathione to various molecules. Among the 42 GSTs identified in Drosophila melanogaster, Delta and Epsilon are the largest classes, with 25 members.
Elodie Gonis +6 more
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Marmoset glutathione transferases with ketosteroid isomerase activity [PDF]
Biochemistry and Biophysics Reports, 2021 The common marmoset Callithrix jacchus encodes two glutathione transferase (GST) enzymes with ketosteroid double-bond isomerase activity. The most active enzyme is CjaGST A3-3 showing a specific activity with 5-androsten-3,17-dione (Δ5-AD) of 62.1 ± 1.8 ...
Aram Ismail +2 more
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Role of Insect and Mammal Glutathione Transferases in Chemoperception [PDF]
Biomolecules, 2023 Glutathione transferases (GSTs) are ubiquitous key enzymes with different activities as transferases or isomerases. As key detoxifying enzymes, GSTs are expressed in the chemosensory organs.
Mathieu Schwartz +10 more
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Allergological Importance of Invertebrate Glutathione Transferases in Tropical Environments [PDF]
Frontiers in Allergy, 2021 Glutathione-S transferases (GSTs) are part of a ubiquitous family of dimeric proteins that participate in detoxification reactions. It has been demonstrated that various GSTs induce allergic reactions in humans: those originating from house dust mites ...
Josefina Zakzuk +2 more
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Plant Glutathione Transferases and Light [PDF]
Frontiers in Plant Science, 2019 The activity and expression of glutathione transferases (GSTs) depend on several less-known endogenous and well-described exogenous factors, such as the developmental stage, presence, and intensity of different stressors, as well as on the absence or ...
Ágnes Gallé +6 more
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Revisiting Glutathione Transferases of Plasmodium as Potential Targets for Coadjuvant Therapies and the Development of New Antimalarials [PDF]
PharmaceuticalsMalaria remains a major global health problem, especially in low- and mid-income countries where Plasmodium parasites are commonly endemic. Despite the significant number of available drugs to treat the disease, some aspects, such as increasing ...
Maria Luiza Lima +4 more
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The Genetic Architecture of Murine Glutathione Transferases. [PDF]
PLoS ONE, 2016 Glutathione S-transferase (GST) genes play a protective role against oxidative stress and may influence disease risk and drug pharmacokinetics. In this study, massive multiscalar trait profiling across a large population of mice derived from a cross ...
Lu Lu +3 more
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Kinetic Behavior of Glutathione Transferases: Understanding Cellular Protection from Reactive Intermediates [PDF]
BiomoleculesGlutathione transferases (GSTs) are the primary catalysts protecting from reactive electrophile attack. In this review, the quantitative levels and distribution of glutathione transferases in relation to physiological function are discussed.
Ralf Morgenstern
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