Results 31 to 40 of about 162,087 (219)

Regulation of Signal Transduction by Glutathione Transferases

International Journal of Hepatology, 2012
Glutathione transferases (GST) are essentially known as enzymes that catalyse the conjugation of glutathione to various electrophilic compounds such as chemical carcinogens, environmental pollutants, and antitumor agents.
Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel, Caroline Aninat   +4 more
doaj   +1 more source

BENZYLIDENE CYCLOPENTANONE DERIVATIVES AS INHIBITORS OF RAT LIVER GLUTATHIONE S-TRANSFERASE ACTIVITIES

Indonesian Journal of Chemistry, 2010
The effect of the curcumin analogues, 2,6-bis-(4-hydroxy-3-methoxy benzylidene) cyclopentanone (B1) and two of its derivatives on m class glutathione S-transferases (GSTs) from phenobarbital-induced and uninduced rat liver cytosol has been studied to ...
Sudibyo Martono
doaj   +1 more source

Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast. [PDF]

PLoS ONE, 2018
Heavy metal and metalloid contaminations are among the most concerning types of pollutant in the environment. Consequently, it is important to investigate the molecular mechanisms of cellular responses and detoxification pathways for these compounds in ...
Houman Moteshareie, Maryam Hajikarimlou, Alex Mulet Indrayanti, Daniel Burnside, Ana Paula Dias, Clara Lettl, Duale Ahmed, Katayoun Omidi, Tom Kazmirchuk, Nathalie Puchacz, Narges Zare, Sarah Takallou, Thet Naing, Raúl Bonne Hernández, William G Willmore, Mohan Babu, Bruce McKay, Bahram Samanfar, Martin Holcik, Ashkan Golshani   +19 more
doaj   +1 more source

Genetic Polymorphisms of Glutathione S-Transferases T1 (GSTT1) and M1 (GSTM1) in Iranian Mandaeans Population

Iranian Journal of Public Health, 2019
Genetic Polymorphisms of Glutathione S-Transferases T1 (GSTT1) and M1 (GSTM1) in Iranian Mandaeans ...
Fariba BOROUMAND, Mahdis ZARGHAMI, Mostafa SAADAT   +2 more
doaj   +1 more source

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Genetics Research, 2023
Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials
Yan Zhang, Xiangdi Meng, Zhaosen Ma, Zhou Sun, Zhixin Wang   +4 more
doaj   +1 more source

RsGSTF12 Contributes to Anthocyanin Sequestration in Radish (Raphanus sativus L.)

Frontiers in Plant Science, 2022
Anthocyanins are water-soluble plant pigments mainly stored in the plant vacuoles. Glutathione S-transferases (GSTs) are a multifunctional enzyme family, which can regulate substance metabolism and biological and abiotic stresses in plants.
Mengyang Niu, Changjian Bao, Jiahui Chen, Wen Zhou, Yueyue Zhang, Xiaoyan Zhang, Nana Su, Jin Cui   +7 more
doaj   +1 more source

Structure and functions of glutathione transferases

The Ukrainian Biochemical Journal, 2014
Data about classification, nomenclature, structure, substrate specificity and role of many glutathione transferase’s isoenzymes in cell functions have been summarised. The enzyme has been discovered more than 50 years ago.
O. M. Fedets
doaj   +1 more source

Genome-wide identification and expression analysis of glutathione S-transferase gene family to reveal their role in cold stress response in cucumber

Frontiers in Genetics, 2022
The plant glutathione S-transferases (GSTs) are versatile proteins encoded by several genes and play vital roles in responding to various physiological processes. Members of plant GSTs have been identified in several species, but few studies on cucumber (
Xiaoyu Duan, Xuejing Yu, Yidan Wang, Wei Fu, Ruifang Cao, Lu Yang, Xueling Ye   +6 more
doaj   +1 more source

Glutathione transferases in maize (zea mays) [PDF]

, 1998
The glutathione transferases (GSTs) of maize have been the most studied GSTs in plants, however much is still not known about these enzymes. In the course of the current study six GST subunits (Zm GSTs I, II and III, which have been reported previously ...
Dixon, D.P., Dixon, David Peter
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source