Results 171 to 180 of about 100,115 (305)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

open access: yesAngewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne   +22 more
wiley   +1 more source

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities. [PDF]

open access: yesAngew Chem Int Ed Engl
Weidler S   +16 more
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

open access: yesAngewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl   +1 more
wiley   +1 more source

Metagenomic Comparison of Bat Colony Resistomes Across Anthropogenic and Pristine Habitats. [PDF]

open access: yesAntibiotics (Basel)
Soto-López JD   +6 more
europepmc   +1 more source

Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N-Functionalization of Heterocycles and Late-Stage Modifications. [PDF]

open access: yesAngew Chem Int Ed Engl
Ospina F   +10 more
europepmc   +1 more source

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