Results 191 to 200 of about 212,981 (331)

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Beyond Single Enzymes: System-Level Fungal Transformation of Halogenated Nitrophenols. [PDF]

J Fungi (Basel)
Aguilar G, Krohn C, Marshall A, Khair Biek S, Besedin JA, Pilcher C, Tottszer A, Khudur LS, Ball AS.   +8 more
europepmc   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Functional characterization of AtAAS as a 5-hydroxytryptophan decarboxylase linking serotonin formation to melatonin metabolism in <i>Arabidopsis thaliana</i>. [PDF]

Front Plant Sci
Guo X, Lin S, Dong C, Huang X, Hu H, Li B, Tan Y, Shu Q.   +7 more
europepmc   +1 more source

Glycosyl transferases in family 61 mediate arabinofuranosyl transfer onto xylan in grasses

Proceedings of the National Academy of Sciences of the United States of America, 2012
Nadine Anders, M. Wilkinson, A. Lovegrove, J. Freeman, T. Tryfona, T. Pellny, T. Weimar, Jenny C. Mortimer, K. Stott, J. Baker, M. Defoin-Platel, P. Shewry, P. Dupree, R. Mitchell   +13 more
semanticscholar   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

Aminoacyl-tRNA-dependent enzymes in natural product biosynthesis: structure-function insights. [PDF]

J Antibiot (Tokyo)
Zheng Y, Zhao Y, Takahashi S.
europepmc   +1 more source

Concise review of the glutathione S-transferases and their significance to toxicology.

Toxicological Sciences, 1999
D. Eaton, T. Bammler
semanticscholar   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Propionic acidemia as a framework for understanding the impact of disturbed propionyl-CoA on histone modifications. [PDF]

Biochem Soc Trans
Swietach P, Gill EK, Holzner LMW.
europepmc   +1 more source