Results 151 to 160 of about 162,073 (298)
MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
Advanced Science, EarlyView.A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak +19 more
wiley +1 more source
Advanced Science, EarlyView.A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li +5 more
wiley +1 more source
Advanced Science, EarlyView.An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li +7 more
wiley +1 more source
Journal of Ovarian ResearchBackground Ovarian cancer (OVCA) is the third most common gynaecological malignancy worldwide. Long non-coding RNA (LncRNA) HCP5 and polypyrimidine tract binding protein 1 (PTBP1) involved in regulating tumors, however, with undefined mechanism in OVCA ...
Xiaoli Chen +4 more
doaj +1 more source
Current Issues in Molecular BiologyThe incidence of primary liver cancer is increasing annually, with extremely high mortality and suboptimal therapeutic outcomes. The inefficient presentation of tumor antigens and low infiltration of specific cytotoxic T lymphocytes (CTLs) result in ...
Huizhong Zhang +12 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
Advanced Science, EarlyView.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
Chelator‐Free Radiometal Labeling Inside Engineered Affibodies
Angewandte Chemie, EarlyView.Affibodies are compact and robust three‑helix binders used in imaging and therapy. Engineering a triple‑cysteine motif into their core enables chelator‑free binding of important radiometals, like Bi(III), Pb(II), In(III), and Ga(III) with rapid uptake and exceptional stability.
Lani J. Davies +6 more
wiley +2 more sources
Annals of Gastroenterological Surgery, EarlyView.HCC patients with low preoperative TIBC levels experienced significantly more frequent post‐hepatectomy complications. Furthermore, these patients were significantly correlated with worse survival. Preoperative serum TIBC levels may be a novel surrogate marker of postoperative complications and long‐term survival after hepatectomy.
Taishi Yamane +9 more
wiley +1 more source
Characterization of the murine cytomegalovirus genes encoding the major DNA binding protein and the ICP18.5 homolog [PDF]
, 1992 In several herpesviruses the genes for the major DNA binding protein (MDBP), a putative assembly protein, the glycoprotein B (gB), and the viral DNA polymerase (pol) coliocate.
Koszinowski, Ulrich H. +3 more
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