Results 271 to 280 of about 162,073 (298)

Biochemical evidence for a conserved interaction between bacterial transferrin binding protein A and transferrin binding protein B

Microbial Pathogenesis, 1998
As an adaptation to the iron-restricted environment of the host, some bacterial pathogens possess iron acquisition pathways mediated by surface receptors that specifically bind transferrin from the host. The receptor is composed of two receptor proteins, TbpA and TbpB, which are both capable of binding to transferrin. Previous studies have demonstrated
C A, Fuller, R, Yu, S W, Irwin, A B, Schryvers   +3 more
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Affinity-Purification of Transferrin-Binding Protein B under Nondenaturing Conditions

Protein Expression and Purification, 2002
The commonly used purification procedures for Transferrin-binding protein B (TbpB) are based on an affinity chromatography step using resins onto which human transferrin had been immobilized. These protocols involve protein elution using denaturing buffer solutions.
Tino, Krell, Michel, Chevalier, Ling, Lissolo   +2 more
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Transferrin binding protein-B from Neisseria meningitidis C as a novel carrier protein in glycoconjugate preparation: an in silico approach

Journal of Biomolecular Structure and Dynamics, 2021
The linking of polysaccharide in glycoconjugate vaccine with carrier protein is an imperative step to develop a strong memory response. The excessive use of similar carrier protein known to result in bystander immunity warrants an urgent need for new carrier protein.
Abhijeet Karale, Kiran Bharat Lokhande, Niraj Shende, K. V. Swamy, Rajeev Dhere, Neelu Nawani, Asha Mallya   +6 more
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Steric and allosteric factors prevent simultaneous binding of transferrin-binding proteins A and B to transferrin

Biochemical Journal, 2012
The ability to acquire iron directly from host Tf (transferrin) is an adaptation common to important bacterial pathogens belonging to the Pasteurellaceae, Moraxellaceae and Neisseriaceae families. A surface receptor comprising an integral outer membrane protein, TbpA (Tf-binding protein A), and a surface-exposed lipoprotein, TbpB (Tf-binding protein B),
Leslie P, Silva, Rong-hua, Yu, Charles, Calmettes, Xue, Yang, Trevor F, Moraes, David C, Schriemer, Anthony B, Schryvers   +6 more
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Characterization of transferrin binding proteins 1 and 2 in invasive type b and nontypeable strains of Haemophilus influenzae

Infection and Immunity, 1995
Haemophilus influenzae has the ability to obtain iron from human transferrin via two bacterial cell surface transferrin binding proteins, Tbp1 and Tbp2. Although a wide array of strains have been shown to express these receptor proteins, two studies have recently identified a series of isolates which appeared to lack the ability to bind transferrin ...
S D, Gray-Owen, A B, Schryvers
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Antigenic and genetic characterization of a putative hybrid transferrin-binding protein B fromNeisseria meningitidis

Canadian Journal of Microbiology, 1999
The transferrin-binding protein Bs (TbpBs) from the bacterium Neisseria meningitidis have been divided into two families according to genetic and antigenic features. TbpB from meningococcal strain B385 showed a molecular mass similar to that exhibited by TbpBs belonging to the high molecular mass family of TbpBs.
T, Menéndez, M, Pérez, A, Alvarez
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Heterogeneity of tbpB, the transferrin-binding protein B gene, among serogroup B Neisseria meningitidis strains of the ET-5 complex

Clinical Diagnostic Laboratory Immunology, 1997
ET-5 complex strains of Neisseria meningitidis were traced intercontinentally and have been causing hyperendemic meningitis on a worldwide scale. In an attempt to develop a fully broad cross-reactive transferrin-binding protein B (TbpB)-based vaccine, we undertook to assess the extent of variability of TbpB proteins among strains of this ...
B, Rokbi, M, Mignon, D A, Caugant, M J, Quentin-Millet   +3 more
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The bacterial receptor protein, transferrin-binding protein B, does not independently facilitate the release of metal ion from human transferrin

Biochemistry and Cell Biology, 2003
Pathogenic Gram-negative bacteria of the Pasteurellaceae and Neisseriaceae acquire iron for growth from host transferrin through the action of specific surface receptors. Iron is removed from transferrin by the receptor at the cell surface and is transported across the outer membrane to the periplasm.
Ulyana, Nemish, Rong-Hua, Yu, Leslie W, Tari, Karla, Krewulak, Anthony B, Schryvers   +4 more
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Discrimination between apo and iron-loaded forms of transferrin by transferrin binding protein B and its N-terminal subfragment

Microbial Pathogenesis, 1998
Many pathogens of the Pasteurellaceae and Neisseriaceae possess a surface receptor that binds transferrin (Tf) as an initial step in an iron acquisition process. This receptor is comprised of two proteins, transferrin binding protein A (TbpA) and transferrin binding protein B (TbpB).
M D, Retzer, R h, Yu, Y, Zhang, G C, Gonzalez, A B, Schryvers   +4 more
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Site-directed mutagenesis of transferrin binding protein B enhances immunogenicity and protective efficacy against Bibersteinia trehalosi

Research in Veterinary Science
Bibersteinia trehalosi (B. trehalosi) is a gram-negative bacterial pathogen that causes respiratory diseases in goats. Its surface transferrin receptor, transferrin binding protein B(TbpB), is an ideal vaccine target as its expression is essential for colonization of the upper respiratory tract.
Zhihao, Yan, Xingyi, Ma, Wenyao, Long, Rongyue, Yang, Jiaquan, Zhu, Chenyu, Wei, Xin, Yu, Ling, Gan, Jianhua, Guo   +8 more
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