Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin+5 more
wiley +1 more source
Revised model for cell cycle regulation by iron: differential roles between transferrin and ferritin. [PDF]
Yanagiya R+12 more
europepmc +1 more source
Studies on Transferrin. I The Binding of Fe<sup>59</sup> with Transferrin In Vitro
Kumiko SHIRASAWA
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Pitstop 2 binds to the clathrin terminal domain. This work explores the nature of the benzylidene moiety, R. The synthesis of 56 novel analogues reveals enhanced potency of a multiple analogues, with catechol‐free 2,3‐dihydroxybenzo[b][1,4]dioxone (54) returning a 1.2 μm IC50, ca 10‐fold more active than Pitstop 2. Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)
Kate Prichard+10 more
wiley +1 more source
The Relationship Between Non-Transferrin-Bound Iron (NTBI), Labile Plasma Iron (LPI), and Iron Toxicity. [PDF]
Duca L+4 more
europepmc +1 more source
Manganese Neurotoxicity and Familial Disorders of Manganese Transport
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley +1 more source
A hematologic composite score integrating iron, coagulation, and inflammation markers predicts diabetic retinopathy severity: a retrospective cross-sectional study. [PDF]
Ma Y, Pei A, Zhao Q.
europepmc +1 more source
Role of Genetic Control and Random Association in Production of Bovine Transferrin Phenotypes
H. C. Hines, T.M. Ludwick, W.H. Rausch
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Removal of iron from human transferrin byNeisseria meningitidis [PDF]
Fred Archibald, I W DeVoe
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