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Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron
Background/Aims: Transferrin receptor 2 appears to have dual roles in iron metabolism; one is signalling, the other is iron transport. It is sensitive to high levels of diferric transferrin, which is associated with disorders of iron overload.
Ross M Graham +2 more
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CSF transferrins characterized by the transferrin/albumin index
Clinica Chimica Acta, 1980Unconcentrated CSF and 200 times diluted serum samples from 192 patients were examined by agar electrophoresis; their albumin and transferrin content were determined simultaneously by radial immunodiffusion. Using the data on transferrin and albumin concentrations in serum and cerebrospinal fluid, the transferrin/albumin index was calculated in a ...
L, Kerényi, M, Koltai, I, Szirmai
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European Journal of Clinical Investigation, 2002
AbstractBackground Cytotoxic agents can be targeted successfully to cancer cells. The efficacy of such novel and potent anticancer strategies may be influenced by variables of iron metabolism.Methods The in vitro cytotoxicity against glioma cells of transferrin (Tf)‐based targeted toxins was compared with that of α‐transferrin receptor (TfR ...
P H, Gosselaar +8 more
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AbstractBackground Cytotoxic agents can be targeted successfully to cancer cells. The efficacy of such novel and potent anticancer strategies may be influenced by variables of iron metabolism.Methods The in vitro cytotoxicity against glioma cells of transferrin (Tf)‐based targeted toxins was compared with that of α‐transferrin receptor (TfR ...
P H, Gosselaar +8 more
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The Transferrin Receptor and the Release of Iron from Transferrin
1994In a classic report detailing the role of transferrin in providing iron to human reticulocytes, Jand1 and coworkers noted that uptake of transferrin-borne iron was saturable as the concentration of transferrin in the culture medium increased, and that uptake was essentially abolished if cells were first exposed to trypsin.
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The physiology of transferrin and transferrin receptors.
Physiological Reviews, 1987H A, Huebers, C A, Finch
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Human transferrin: An inorganic biochemistry perspective
Coordination Chemistry Reviews, 2021André M N Silva +2 more
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