Results 21 to 30 of about 165,649 (342)

Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

Nature Communications, 2019
Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Arenaviruses and the malaria parasite exploit CD71 for cell invasion and epitopes on CD71 for interaction with transferrin and
L. C. Montemiglio, Claudia Testi, P. Ceci, E. Falvo, M. Pitea, C. Savino, A. Arcovito, G. Peruzzi, P. Baiocco, F. Mancia, A. Boffi, Amédée des Georges, B. Vallone   +12 more
semanticscholar   +1 more source

Transferrin Functionalized Liposomes Loading Dopamine HCl: Development and Permeability Studies across an In Vitro Model of Human Blood–Brain Barrier

Nanomaterials, 2018
The transport of dopamine across the blood brain barrier represents a challenge for the management of Parkinson’s disease. The employment of central nervous system targeted ligands functionalized nanocarriers could be a valid tactic to overcome this ...
Antonio Lopalco, Annalisa Cutrignelli, Nunzio Denora, Angela Lopedota, Massimo Franco, Valentino Laquintana   +5 more
doaj   +1 more source

Iron metabolism and peripheral eosinophil count do not correlate in the general population

Journal of Biological Research, 2023
Iron is a primary component of the human body and exerts many functions, mainly concerning red cells and the immune system. In addition, there is evidence that iron-deficiency anemia is associated with allergic diseases. Type 2 inflammation characterizes
Mara De Amici, Riccardo Albertini, Fiorella Barocci, Tiziana Bosoni, Laura Maria Ciardelli, Annalisa De Silvestri, Gian Luigi Marseglia, Giorgio Ciprandi   +7 more
doaj   +1 more source

Abnormal Serum Iron-Status Indicator Changes in Amyotrophic Lateral Sclerosis (ALS) Patients: A Meta-Analysis

Frontiers in Neurology, 2020
Background: In recent years, the role of iron metabolism in amyotrophic lateral sclerosis (ALS) attracts more and more attention, and some studies have focused on the link between abnormal serum iron indicators and ALS.
Lan Wang, Chunyu Li, Xueping Chen, Shuying Li, Huifang Shang   +4 more
doaj   +1 more source

Polymorphism of Transferrin Gene Impacts the Mediating Effects of Psychotic Symptoms on the Relationship between Oxidative Stress and Cognition in Patients with Chronic Schizophrenia

Antioxidants, 2022
A series of studies indicated that iron distribution that partly derives from transferrin-bound iron in the peripheral nervous system in the brain may act in processes such as myelination and brain development.
Pinhong Chen, Dongmei Wang, Meihong Xiu, Dachun Chen, Blake Lackey, Hanjing E. Wu, Jin Zhou, Xiangyang Zhang   +7 more
doaj   +1 more source

Urea Gel Electrophoresis in Studies of Conformational Changes of Transferrin on Binding and Transport of Non-Ferric Metal Ions

Gels, 2021
Transferrin (Tf) is a crucial transporter protein for Fe(III), but its biological role in binding other metal ions and their delivery into cells remain highly controversial.
Aviva Levina, Boer Wang, Peter A. Lay
doaj   +1 more source

Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.

Blood, 2019
Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Its critical physiological function is highlighted by the embryonic lethal phenotype of Tfr1-knockout (Tfrc-/-) mice ...
C. Fillebeen, Edouard Charlebois, J. Wagner, A. Katsarou, J. Mui, H. Vali, Daniel Garcia-Santos, P. Ponka, J. Presley, K. Pantopoulos   +9 more
semanticscholar   +1 more source

Transferrin as a source of iron for Campylobacter rectus

Journal of Oral Microbiology, 2011
Background and Objective: Campylobacter rectus is considered as one of the bacterial species of etiological importance in periodontitis. Iron-containing proteins such as transferrin are found in periodontal sites and may serve as a source of iron for ...
Daniel Grenier, Shin-ichi Tanabe
doaj   +1 more source

An Improved Method for Quick Quantification of Unsaturated Transferrin

Biosensors, 2022
Blood iron levels play a vital role in oxygen metabolism and energy generation whilst transporter protein, transferrin, binds and delivers iron to the transferrin receptor of endosomal compartments of cells.
Ruirui Guo, Juanjuan Gao, Lingyun Hui, Yanqing Li, Junhui Liu, Yao Fu, Lei Shi, Yawen Wang, Bing Liu   +8 more
doaj   +1 more source

Novel O-Methylglucoside Derivatives of Flavanone in Interaction with Model Membrane and Transferrin

Membranes, 2022
Flavonoids were biotransformed using various microorganisms, in order to obtain new compounds with potentially high biological activity. The aim of this work was to determine and compare the biological activity of four novel 6-methylflavanone O ...
Sylwia Cyboran-Mikołajczyk, Dorota Bonarska-Kujawa, Katarzyna Męczarska, Agnieszka Krawczyk-Łebek, Edyta Kostrzewa-Susłow   +4 more
doaj   +1 more source