Results 21 to 30 of about 128,806 (310)

Transferrin as a source of iron for Campylobacter rectus

Journal of Oral Microbiology, 2011
Background and Objective: Campylobacter rectus is considered as one of the bacterial species of etiological importance in periodontitis. Iron-containing proteins such as transferrin are found in periodontal sites and may serve as a source of iron for ...
Daniel Grenier, Shin-ichi Tanabe
doaj   +1 more source

Urea Gel Electrophoresis in Studies of Conformational Changes of Transferrin on Binding and Transport of Non-Ferric Metal Ions

Gels, 2021
Transferrin (Tf) is a crucial transporter protein for Fe(III), but its biological role in binding other metal ions and their delivery into cells remain highly controversial.
Aviva Levina, Boer Wang, Peter A. Lay
doaj   +1 more source

Transferrin-modified cancer cell member coating hypocrellin B-derived nanomaterials for enhanced photodynamic therapy efficacy in hepatocellular carcinoma

Medicine in Drug Discovery, 2021
Hepatocellular carcinoma (HCC) has been reported to be the third common malignant tumor because of the high rate of mortality. Photosensitizers (PSs) based on the natural products have been widely used in clinical antitumor research contributed to their ...
Zhiqiang Zhang, Xianghui Li, Kai Zhao, Zhenhuan Guo, Yonglu Liu, Dai Zeng, Xueting Ban, Li Zhao, Xia Ma, Shizhong Zheng   +9 more
doaj   +1 more source

Transferrin Receptor-Targeted Nanocarriers: Overcoming Barriers to Treat Glioblastoma

Pharmaceutics, 2022
Glioblastoma multiforme (GBM) is the most common and lethal type of brain tumor, and the clinically available approaches for its treatment are not curative.
Maria João Ramalho, Joana Angélica Loureiro, Manuel A. N. Coelho, Maria Carmo Pereira   +3 more
doaj   +1 more source

Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer

Pharmaceutics, 2021
The co-delivery of chemotherapeutic agents and immune modulators to their targets remains to be a great challenge for nanocarriers. Here, we developed a hybrid thermosensitive nanoparticle (TMNP) which could co-deliver paclitaxel-loaded transferrin (PTX ...
Kai Zhang, Jingjing Li, Xiaofei Xin, Xiaoqing Du, Di Zhao, Chao Qin, Xiaopeng Han, Meirong Huo, Lei Yang, Lifang Yin   +9 more
doaj   +1 more source

Transferrin receptors

Experimental & Molecular Medicine
Abstract The transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body. Over the past three decades, the studies on TfR have made significant progress, and also, our knowledge on cell iron uptake
Qian Guo, Christopher Qian, Xinyu Wang, Zhong-Ming Qian   +3 more
openaire   +3 more sources

Delivery of Nanoparticles across the Intestinal Epithelium via the Transferrin Transport Pathway

Pharmaceutics, 2019
The aim of this study was to probe whether the transferrin (Tf) transport pathway can be exploited for intestinal delivery of nanoparticles. Tf was adsorbed on 100 nm model polystyrene nanoparticles (NP), followed by size characterisation of these ...
Jing M. Yong, Julia Mantaj, Yiyi Cheng, Driton Vllasaliu   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Variation of the serum N‐glycosylation during the pregnancy of a MPI‐CDG patient

JIMD Reports, 2021
For the first time the glycosylation of a patient with a MPI‐CDG during pregnancy is monitored. MPI‐CDG, is characterised by a deficiency in mannose‐6‐phosphate isomerase (MPI) leading to a reduced pool of glycosylation precursors, impairing the ...
Elodie Lebredonchel, Sandrine Duvet, Claire Douillard, François Foulquier, André Klein   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source