Results 191 to 200 of about 75,793 (264)

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations. [PDF]

Signal Transduct Target Ther
Hou Y, Tang G, Wang Q, Zhou M, Xu R, Chen X, Shi G, Wang Z, Yan X, Zhuang J, Fan K.   +10 more
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Selective Transfection of a Transferrin Receptor-Expressing Cell Line with DNA-Lipid Nanoparticles. [PDF]

ACS Omega
Vinales I, Silva-Espinoza JC, Medina BA, Urbay JEM, Beltran MA, Salinas DE, Ramirez-Ramos MA, Maldonado RA, Poon W, Penichet ML, Almeida IC, Michael K.   +11 more
europepmc   +1 more source

National Bleeding Disorder Foundation Clinical Practice Recommendations for Laboratory Screening of Iron Deficiency With and Without Anemia in the Inherited Bleeding Disorders Population

Haemophilia, EarlyView.
ABSTRACT Introduction The National Bleeding Disorder Foundation (NBDF) Medical and Scientific Advisory Council (MASAC) was formed in 1954 and issues recommendations and advisories pertinent to the bleeding disorders community. MASAC is comprised of > 25 rotating members from different medical disciplines and lived experience experts.
Glaivy Batsuli, Magdalena D. Lewandowska, Ming Y. Lim, Kelly Tickle, Maureen K. Baldwin, Rose Bender, Jennifer Davila, Brendan Hayes, Amanda Jacobson‐Kelly, Peter Kouides, Michele P. Lambert, Shilpa Nataraj, Michelle Sholzberg, Roona Sinha, Hanny Al‐Samkari, Amy L. Dunn   +15 more
wiley   +1 more source

Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles. [PDF]

Nucleic Acids Res
Østergaard ME, Carrer M, Anderson BA, Afetian M, Bakooshli MA, Santos JA, Klein SK, Capitanio J, Freestone GC, Tanowitz M, Galindo-Murillo R, Gaus HJ, Dwyer CA, Jackson M, Jafar-Nejad P, Rigo F, Seth PP, Gaynor KU, Stanway SJ, Urbonas L, St Denis MA, Pellegrino S, Bezerra GA, Rigby M, Gowans E, Van Rietschoten K, Beswick P, Chen L, Skynner MJ, Swayze EE.   +29 more
europepmc   +1 more source

Unexplained Elevated Vitamin B12: Consider Macro‐B12

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Elevated vitamin B12 concentration can be caused by supplementation, liver disease, kidney disease, or myeloid malignancies. Persistent, unexplained elevations of vitamin B12 can raise concern among patients and may lead to invasive diagnostic procedures, including bone marrow biopsy.
Evelien G. E. Hurkmans, Ruben Deneer, Marten R. Nijziel, Volkher Scharnhorst   +3 more
wiley   +1 more source

Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model. [PDF]

Drug Deliv
Mi L, Yuan J, Jiang Y, Hu Y, Lv C, Xu Y, Liu M, Liu T, Liu X, Huang J, Jiang R, Quan W.   +11 more
europepmc   +1 more source

Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta, Tong Wang, Susmita, Ditte Marie L. Saunte, Roderick Hay, Vincent Piguet   +5 more
wiley   +1 more source

Transferrin receptor uptakes iron from tumor-associated neutrophils to regulate invasion patterns of OSCC. [PDF]

Cancer Immunol Immunother
Si Q, Wang Y, Lu W, Liu Z, Song Y, Chen S, Xia S, Li H, Weng P, Jing Y, Yu Q, Zhu F, Zhang X, Huang X, Ni Y.   +14 more
europepmc   +1 more source