Results 231 to 240 of about 133,411 (307)

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy. [PDF]

Nat Commun
Si M, Fu J, Fang M, Lu Y, Huang J, Li H, Wang P, Liao M, Zhu J, Li P, Zhong W, Guo Z, Yang W, Ye Z, Hu H, Yu X.   +15 more
europepmc   +1 more source

Image Analysis Platform for Comprehensive Quantification of Extracellular Vesicle Morphology

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐encapsulated nanoparticles with key roles in cell biology and growing importance in biomedicine. However, EVs are challenging to characterize because they are highly heterogeneous. Single EV analysis methods are valuable tools for addressing this challenge.
Alexander Spark, Nan Jiang, Benjamin Purnell, Mihajlo Radmilovic, Andras Saftics, Eugenia Romano, Tijana Jovanovic‐Talisman, Alexandre Kitching   +7 more
wiley   +1 more source

Bone phenotype in male and female mice after knockdown of transferrin receptor 1 in osterix-expressing cells. [PDF]

JBMR Plus
Passin V, Ledesma-Colunga MG, Baschant U, Hofbauer LC, Rauner M, Rauner M.   +5 more
europepmc   +1 more source

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications

Small, EarlyView.
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito, Mariana B. Oliveira, João F. Mano   +2 more
wiley   +1 more source

Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model. [PDF]

J Cereb Blood Flow Metab
Torres VO, Pizzo ME, Chan D, Dugas JC, Huynh D, Joy D, Liang EK, Sarrafha L, Becerra I, Chau R, Chew KS, Chow J, Discenza CB, Earr TK, Furaso L, Khoury N, Lechtenberg KJ, Leung AW, Nguyen HN, Ojo ES, Roche E, Simon MJ, Solanoy H, Tong M, Tong RK, Henne K, Lewcock JW, Watts RJ, Calvert ME, Thorne RG, Zuchero YJY.   +30 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas. [PDF]

Animals (Basel)
Leandri R, Buonocore S, Power K.
europepmc   +1 more source

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems

The Chemical Record, EarlyView.
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez, Tielle Moraes de Almeida, Daiani Canabarro Leite, Gilson Zeni   +3 more
wiley   +1 more source

Transferrin receptor knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis. [PDF]

Exp Anim
Zhan Y, Zhou Y, Zhang C, Zhai Z, Yang Y, Liu X.   +5 more
europepmc   +1 more source