Results 221 to 230 of about 133,411 (307)

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice. [PDF]

Hypertens Res
Naito Y, Sawada H, Horimatsu T, Ohmuraya M, Asakura M, Ishihara M.   +5 more
europepmc   +1 more source

Inflammation and Erythropoietin Resistance in Chronic Kidney Disease: A Cross‐Sectional Study of C‐Reactive Protein and Anemia in Hemodialysis Patients

Journal of Clinical Laboratory Analysis, EarlyView.
This study examined the role of inflammation in anemia among patients with chronic kidney disease on maintenance hemodialysis. Elevated C‐reactive protein (CRP) levels were associated with reduced iron availability, lower hematocrit, and increased erythropoietin requirements.
Collince Odiwuor Ogolla, Lucy W. Karani, Stanslaus Musyoki, Phidelis Maruti   +3 more
wiley   +1 more source

Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and plaque-clearing efficacy of a therapeutic anti-Aβ antibody. [PDF]

Fluids Barriers CNS
Vega MR, Hansen HH, Jensen CS, Alexiou E, Madsen MR, Wichern F, Kristiansen MS, Skytte JL, Salinas CG, Sotty F, Jensen A, Vergo S, Hecksher-Sørensen J.   +12 more
europepmc   +1 more source

Enrichment of Hyaluronic Acid Binding Tumor Cells by Modulation of Selective Adhesion on Microgel Surfaces

Macromolecular Rapid Communications, EarlyView.
We have developed a thermoresponsive microgel system for the selective enrichment of hyaluronic acid‐binding tumor cells. By modulating the adhesion on the microgel surface via temperature changes from 37°C to 30°C, we demonstrate a novel proof‐of‐principle for separating these tumor cell from white blood cells, which has potential applications in ...
Melanie Schmidt, Dilay Karayel, André Franken, Janita Müller, Laura Hartmann, Klaus Pantel, Tanja Fehm, Hans Neubauer, Stephan Schmidt   +8 more
wiley   +1 more source

Synthesis and Characterization of Transferrin Receptor-Targeted Peptide Combination SN-38 and Rucaparib Conjugate for the Treatment of Glioblastoma. [PDF]

Pharmaceutics
Bataille Backer P, Adesina SK.
europepmc   +1 more source

Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery

Neuroprotection, EarlyView.
Abstract Aim Aromatase is the key enzyme in the biosynthesis of 17β‐estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variants increase susceptibility to stroke. This study aims to determine whether aromatase overexpression improves stroke outcome and
Lindsay Gallagher, Anna F. Dominiczak, Luis M. Garcia‐Segura, Nobuhiro Harada, J. B. Hutchison, James M. Mullin, Delyth Graham, Peter O'Shaughnessy, Hilary Victoria O. Carswell   +8 more
wiley   +1 more source

Translational minimal physiologically based pharmacokinetic model for transferrin receptor-mediated brain delivery of antibodies. [PDF]

MAbs
Muliaditan M, van Steeg TJ, Avery LB, Sun W, Hammond TR, Hijdra D, Choi SL, Pillai N, Leksa NC, Mavroudis PD.   +9 more
europepmc   +1 more source

The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet‐Induced and Genetically Obese Mice

Obesity, EarlyView.
ABSTRACT Objective We aimed to examine the effect of obesity on the plasma free fatty acid (FFA) carrier proteome in mice. Methods From 6 to 20 weeks of age, male and female C57BL/6J wild‐type mice were fed either a low‐fat diet (10% of kilocalories from fat) or a high‐fat diet (60% of kilocalories from fat), and leptin‐deficient ob/ob mice were fed a ...
Keigo Tomoo, Yi Zhang, Ariana Zoe Diaz Portalatin, Gregory C. Henderson   +3 more
wiley   +1 more source