Results 51 to 60 of about 2,476,356 (396)

Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor [PDF]

, 2003
Transferrin receptor 1 (TfR) plays a critical role in cellular iron import for most higher organisms. Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate ...
Björkman, Pamela J, Giannetti, Anthony M, Snow, Peter M, Zak, Olga   +3 more
core   +5 more sources

The extrahepatic role of TFR2 in iron homeostasis

Frontiers in Pharmacology, 2014
Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer transferrin receptor 1 (TFR1), is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1.
Laura eSilvestri, Antonella eNai, Alessia ePagani, Clara eCamaschella   +3 more
doaj   +1 more source

The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating progressive disease with limited therapeutic options. Airway macrophages (AMs) are key components of the defense of the airways and are implicated in the pathogenesis of IPF.
Sarah Allden, P. Ogger, P. Ghai, P. McErlean, R. Hewitt, R. Toshner, S. Walker, P. Saunders, S. Kingston, P. Molyneaux, T. Maher, C. Lloyd, A. Byrne   +12 more
semanticscholar   +1 more source

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology

Haematologica, 2015
Clathrin-dependent endocytosis is an essential cellular process shared by all cell types. Despite this, precisely how endocytosis is regulated in a cell-type-specific manner and how this key pathway functions physiologically or pathophysiologically ...
Yuichi Ishikawa, Manami Maeda, Mithun Pasham, Francois Aguet, Silvia K. Tacheva-Grigorova, Takeshi Masuda, Hai Yi, Sung-Uk Lee, Jian Xu, Julie Teruya-Feldstein, Maria Ericsson, Ann Mullally, John Heuser, Tom Kirchhausen, Takahiro Maeda   +14 more
doaj   +1 more source

H-Ferritin Is Preferentially Incorporated by Human Erythroid Cells through Transferrin Receptor 1 in a Threshold-Dependent Manner. [PDF]

PLoS ONE, 2015
Ferritin is an iron-storage protein composed of different ratios of 24 light (L) and heavy (H) subunits. The serum level of ferritin is a clinical marker of the body's iron level.
Soichiro Sakamoto, Hiroshi Kawabata, Taro Masuda, Tatsuki Uchiyama, Chisaki Mizumoto, Katsuyuki Ohmori, H Phillip Koeffler, Norimitsu Kadowaki, Akifumi Takaori-Kondo   +8 more
doaj   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Birnstiel, Max L., Clausen, Henrik, Cotten, Matt, Dinter, André, Mechtler, Karl, Rusconi, Sandro, Thurnher, Martin, Wagner, Ernst   +8 more
core   +2 more sources

Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis

Haematologica, 2019
Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis. To study the role of Tfr1 in hematopoiesis, we generated hematopoietic stem
Shufen Wang, Xuyan He, Qian Wu, Li Jiang, Liyun Chen, Yingying Yu, Pan Zhang, Xin Huang, Jia Wang, Z. Ju, J. Min, Fudi Wang   +11 more
semanticscholar   +1 more source

Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei.

PLoS Pathogens, 2012
The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance glycoprotein with a single glycosylphosphatidylinositol membrane anchor and eight potential N ...
Angela Mehlert, Mark R Wormald, Michael A J Ferguson   +2 more
doaj   +1 more source

Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway [PDF]

, 1993
Molecular conjugate vectors may be constructed that accomplish high efficiency gene transfer by the receptor-mediated endocytosis pathway. In order to mediate escape from lysosomal degradation, we have incorporated adenoviruses into the functional design
Curiel, David T., Hu, P.-C., Huang, C. H., Michael, S. I., Romer, M., Wagner, Ernst   +5 more
core   +2 more sources

Transferrin receptor in primary and metastatic breast cancer: Evaluation of expression and experimental modulation to improve molecular targeting.

PLoS ONE, 2023
BackgroundConjugation of transferrin (Tf) to imaging or nanotherapeutic agents is a promising strategy to target breast cancer. Since the efficacy of these biomaterials often depends on the overexpression of the targeted receptor, we set out to survey ...
Francesca Fontana, Alison K Esser, Christopher Egbulefu, Partha Karmakar, Xinming Su, John S Allen, Yalin Xu, Jennifer L Davis, Ariel Gabay, Jingyu Xiang, Kristin A Kwakwa, Brad Manion, Suzanne Bakewell, Shunqiang Li, Haeseong Park, Gregory M Lanza, Samuel Achilefu, Katherine N Weilbaecher   +17 more
doaj   +1 more source