Results 51 to 60 of about 364,066 (237)

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Relationships Between Markers of Iron Status and Hematological Parameters in Patients With Sickle Cell Disease

Advances in Hematology
Based on the relationship between the intracellular concentration of sickle hemoglobin S (HbS) and the delay that occurs prior to the onset of sickling following deoxygenation, targeting the intracellular HbS concentration is a recognized therapeutic ...
Nermi L. Parrow, Jason M. Doherty, Anna Conrey, Swee Lay Thein, Robert E. Fleming   +4 more
doaj   +1 more source

Influence of serum transferrin concentration on diagnostic criteria for iron deficiency in chronic heart failure

ESC Heart Failure, 2023
Aims Transferrin saturation (TSAT), a marker of iron deficiency, reflects both serum concentrations of iron (SIC) and transferrin (STC). TSAT is susceptible to changes in each of these biomarkers.
Fraser J. Graham, Pierpaolo Pellicori, Gabriele Masini, Joseph J. Cuthbert, Andrew L. Clark, John G. F. Cleland   +5 more
doaj   +1 more source

The causal association between iron status and the risk of autism: A Mendelian randomization study

Frontiers in Nutrition, 2022
Emerging evidence indicates a connection between serum iron levels and autism, but the underlying causal association is yet unclear. Thus, we performed two-sample Mendelian randomization (MR) analysis to evaluate the causal link between iron status on ...
Li Chen, Li Chen, Xingzhi Guo, Xingzhi Guo, Xingzhi Guo, Chen Hou, Chen Hou, Peng Tang, Peng Tang, Xin Zhang, Xin Zhang, Li Chong, Li Chong, Rui Li, Rui Li, Rui Li   +15 more
doaj   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Iron Deficiency Is Associated With Impaired Myocardial Reperfusion in ST‐Segment–Elevation Myocardial Infarction: Influence of the Definition Used

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The role of iron deficiency (ID) in ST‐segment–elevation myocardial infarction (STEMI) remains unclear. This study aimed to assess whether ID is associated with impaired myocardial reperfusion in STEMI and whether this association is affected ...
José A. Barrabés, Javier Inserte, Laura Castellote, Irene Buera, Laia Milà, Antonia Sambola, Aitor Uribarri, Maria Vidal, David Aluja, Sara Delgado‐Tomás, Pablo E. Tobías‐Castillo, Maria Calvo‐Barceló, Andrea Guala, José F. Rodríguez‐Palomares, Bruno García del Blanco, David Beneítez, Ignacio Ferreira‐González   +16 more
doaj   +1 more source

Serum Ferritin and Transferrin Saturation in Asians and Pacific Islanders [PDF]

Archives of Internal Medicine, 2007
Asians and Pacific Islanders in the Hemochromatosis and Iron Overload Screening (HEIRS) Study had the highest prevalence of elevated serum ferritin (SF) and transferrin saturation (TS) levels, but to our knowledge, the reasons for this have not been investigated.Using multiple linear regression, we compared TS and SF distributions for 42 720 Asian ...
Emily L, Harris, Christine E, McLaren, David M, Reboussin, Victor R, Gordeuk, James C, Barton, Ronald T, Acton, Gordon D, McLaren, Thomas M, Vogt, Beverly M, Snively, Catherine, Leiendecker-Foster, Joan L, Holup, Leah V, Passmore, John H, Eckfeldt, Edward, Lin, Paul C, Adams   +14 more
openaire   +2 more sources

MO519: Ferric Citrate Hydrate Improves Levels of Transferrin Saturation in Hemodialysis Patients With Lower Levels of Transferrin Saturation

Nephrology Dialysis Transplantation, 2022
Abstract BACKGROUND AND AIMS Iron deficiency identified by transferrin saturation (TSAT) is reported as a risk factor for all-cause mortality and cardiovascular events in non-dialysis dependent (NDD) chronic kidney disease (CKD) [1, 2] and for all-cause mortality in hemodialysis patients [3].
Keitaro Yokoyama, Ryo Inoue, Kyoko Ito, Yuko Mitobe, Yu Matsumoto, Ryoichi Yamada, Hiroyuki Susai, Noriaki Nishino   +7 more
openaire   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Correlation of Serum Ferritin and Liver Iron Concentration with Transient Liver Elastography in Adult Thalassemia Intermedia Patients with Blood Transfusion

Journal of Blood Medicine, 2021
Tubagus Djumhana Atmakusuma, Anna Mira Lubis Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaCorrespondence: Tubagus Djumhana ...
Atmakusuma TD, Lubis AM
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