Results 81 to 90 of about 5,482,088 (343)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]

, 2019
Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K, Deutschbauer, Adam M, Kothari, Ankita, Mukhopadhyay, Aindrila, Soneja, Drishti, Tang, Albert   +5 more
core   +1 more source

Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta [PDF]

, 2010
IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs.
Bishop, S.C., Burchmore, R.J.S., Eckersall, P.D., Huntley, J.F., Murphy, L., Pettit, J.J., Stear, M.J.   +6 more
core   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Significant variation in transformation frequency in Streptococcus pneumoniae [PDF]

, 2013
The naturally transformable bacterium Streptococcus pneumoniae is able to take up extracellular DNA and incorporate it into its genome. Maintaining natural transformation within a species requires that the benefits of transformation outweigh its costs ...
A Tomasz, A Tomasz, AM Whatmore, Benjamin A Evans, BJ Haijema, CG Dowson, CG Dowson, CS Wylie, D Bogaert, D Bogaert, Daniel E Rozen, DF Vestrheim, DL Wilson, E Libby, F Griffith, F Iannelli, G Pozzi, H Bernstein, H Maughan, H Steinmoen, HJ Beaumont, I Chen, I Mortier-Barriere, J Corander, J Majewski, J Majewski, J Sikorski, J Yang, JP Claverys, KL O'Brien, L Hadany, LS Havarstein, M Carrolo, M Prudhomme, M Travisano, M Vos, MC Enright, MC Enright, MG Lorenz, MJ Ferrandiz, ML Joloba, NJ Croucher, O Fujise, O Gutierrez, OE Cornejo, OT Avery, PJ Johnsen, RJ Redfield, RJ Redfield, RJ Redfield, S Schoustra, SA West, SN Peterson, SP Otto, WP Hanage, X Didelot, YC Hsieh   +56 more
core   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Interactions of Bacillus Mojavensis and Fusarium Verticillioides With a Benzoxazolinone (Boa) and Its Transformation Product, Apo [PDF]

, 2007
En:Journal of Chemical Ecology (2007, vol. 33, n. 10, p. 1885-1897)The benzoxazolinones, specifically benzoxazolin-2(3H)-one (BOA), are important transformation products of the benzoxazinones that can serve as allelochemicals providing resistance to ...
A. Baumeler, A. E. Glenn, A. E. Glenn, A. E. Glenn, A. Friebe, A. Friebe, A. Givovich, A. I. Virtanen, A. S. Atwal, Anthony E. Glenn, C. W. Bacon, C. W. Bacon, C. W. Bacon, C. W. Bacon, C. W. Bacon, Charles W. Bacon, David Marin, Dorothy M. Hinton, E. Wang, F. A. Macias, Francisco A. Macías, G. Nair, H. Hartenstein, H. M. Niemeyer, I. S. Fomsgaard, I. S. Fomsgaard, J. A. Klun, J. G. Waes, J. I. Fritz, K. A. Voss, K. Anzai, K. Pratt, L. J. Corcuera, L. M. Hansen, M. Frey, M. G. Koziel, M. Knop, M. Zikmundova, N. Gerber, N. J. Whitney, O. Wahlroos, P. A. Hedin, Q. Yue, R. M. Couture, R. T. Riley, R. T. Riley, R. W. Gagliardo, S. Martyniuk, S. S. Krogh, S. V. Copaja, T. Kommedahl, V. Cambier, V. H. Argandona, V. Vilich, W. F. O. Marasas, W. F. O. Marasas   +55 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source