Results 91 to 100 of about 7,948,396 (393)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Entanglement-assisted transformation is asymptotically equivalent to multiple-copy transformation

, 2004
We show that two ways of manipulation of quantum entanglement, namely, entanglement-assisted local transformation [D. Jonathan and M. B. Plenio, Phys. Rev. Lett. {\bf 83}, 3566 (1999)] and multiple-copy transformation [S. Bandyopadhyay, V.
C. H. Bennett, Mingsheng Ying, Runyao Duan, Yuan Feng   +3 more
core   +1 more source

Unveiling the twin epidemics of hypertension and diabetes: a cross-sectional analysis of sex-specific prevalence, risk, and hotspots in India’s epidemiological transition zones

BMC Public Health
Background The prevalence of hypertension and diabetes, which often coexist and significantly contribute to the burden of noncommunicable diseases (NCDs), is increasing in India.
Nishikant Singh, Sudheer Kumar Shukla, Pratheeba John, Rimjhim Bajpai, Prince Chugh, Rituparna Sengupta, Ritesh Ranjan Pushkar, Nishant Yadav, Navin Singh, Rajeev Sadanandan   +9 more
doaj   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Partnerships for Transformation [PDF]

, 2013
The ecosystem of foundations and philanthropy is incredibly diverse, similarly to the private sector ecosystem, and this diversity has enabled a great deal of innovation in providing solutions to sustainable development challenges.

core  

Neural Nets via Forward State Transformation and Backward Loss Transformation

, 2018
This article studies (multilayer perceptron) neural networks with an emphasis on the transformations involved --- both forward and backward --- in order to develop a semantical/logical perspective that is in line with standard program semantics.
Jacobs, Bart, Sprunger, David
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Supersymmetric KdV equation: Darboux transformation and discrete systems

, 2013
For the supersymmetric KdV equation, a proper Darboux transformation is presented. This Darboux transformation leads to the B\"{a}cklund transformation found early by Liu and Xie \cite{liu2}.
Levi, D., Liu, Q. P., Xue, Ling-Ling
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Transformation in HaRe [PDF]

, 2004
HaRe [?] is a system developed at the University of Kent Computing Laboratory to support refactoring in Haskell. We also want HaRe to be an open platform to support general Haskell program transformation so it can be used by other researchers in the ...
Nguyen-Viet, Chau
core