Results 91 to 100 of about 6,507,008 (334)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Impact of Diabetes Mellitus on Atrial Fibrillation Recurrence and Major Adverse Cardiac and Cerebrovascular Events following Catheter Ablation

International Journal of Clinical Practice
Introduction. Further evidence is required to understand the impact of preexisting and newly diagnosed diabetes mellitus (DM) on atrial fibrillation (AF) recurrence and major adverse cardiac and cerebrovascular events (MACCEs) following catheter ablation.
Mingjie Lin, Juntao Wang, Bing Rong, Kai Zhang, Tongshuai Chen, Wenqiang Han, Tong Hu, Tianyu Wang, Haonan Deng, Jingquan Zhong, Lin Wu   +10 more
doaj   +1 more source

The great transformation: decarbonising Europeâ??s energy and transport systems [PDF]

The euro-area crisis dominates the economic news. Yet, the world and Europe may face even more important challenges that will shape our lives and the lives of our children.World population is projected to increase to 9 billion or more by 2050.
Anta Ndoye, Dmytro Naumenko, Georg Zachmann, Jörg Radeke, Mark Huberty, Michael Holtermann, Mimi Tam   +6 more
core   +1 more source

The TTC 2013 Flowgraphs Case

, 2013
This case for the Transformation Tool Contest 2013 is about evaluating the scope and usability of transformation languages and tools for a set of four tasks requiring very different capabilities.
Horn, Tassilo
core   +2 more sources

Systems thinking as a paradigm shift for sustainability transformation

, 2022
Nikolaos Voulvoulis, Theodoros Giakoumis, Claire F. Hunt, Vasiliki Kioupi, Kleoniki Natalia Petrou, Ioannis Souliotis, Chetna Vaghela, Wan Izar Haizan Wan Rosely   +7 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Inverse Transformation Optics and Reflection Analysis for Two-Dimensional Finite Embedded Coordinate Transformation

, 2009
Inverse transformation optics is introduced, and used to calculate the reflection at the boundary of a transformation medium under consideration. The transformation medium for a practical device is obtained from a two-dimensional (2D) finite embedded ...
He, Sailing, Jin, Yi, Zhang, Pu
core   +1 more source

Galilean Transformation, Lorentz Transformation, and General Transformation

, 2022
Abstract In the Galilean transformation system, a body contacts and moves on the moving frame and is completely carried by the moving frame and hence the body and the moving frame have the same time rule but velocity of the body moving in the stationary frame is larger than in the moving frame.
openaire   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source