Results 131 to 140 of about 6,636,483 (334)

Simulating the healthcare workforce impact and capacity for pancreatic cancer care in Victoria: a model-based analysis

BMC Health Services Research
Background The incidence of pancreatic cancer is rising. With improvements in knowledge for screening and early detection, earlier detection of pancreatic cancer will continue to be more common.
Lan Gao, Anna Ugalde, Patricia M Livingston, Victoria White, Jennifer J Watts, Hannah Jongebloed, Nikki McCaffrey, David Menzies, Suzanne Robinson   +8 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The role of alcohol consumption in the lives of older Australian women: qualitative insights and an agenda for further research, policy and practice

BMC Public Health
Background Alcohol consumption presents a threat to the health and wellbeing of women. The alcohol industry often pushes back at global efforts to prioritise the prevention of alcohol harms to women.
Simone McCarthy, Hannah Pitt, Kelli Benjamin, Julia Stafford, Danica Keric, Grace Arnot, Samantha Thomas   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

How much is invested in obesity prevention in Australia? An analysis of major research and Federal Government funding, 2013–2022

Public Health Research & Practice
Objective and importance of study: Overweight and obesity are the second leading risk factors for death and non-communicable disease in Australia. This study aimed to examine the Australian Federal Government funding landscape for population-level ...
Huong Ngoc Quynh Tran, Moosa Al Subhi, Nicole Ward, Phuong Nguyen, Marufa Sultana , Jaithri Ananthapavan, Vicki Brown   +6 more
doaj   +1 more source

A multimodal GeoAI approach to combining text with spatiotemporal features for enhanced relevance classification of social media posts in disaster response

Big Earth Data
Geo-referenced social media data supports disaster management by offering real-time insights through user-generated content. To identify critical information amid high volumes of noise, classifying the relevance of posts is essential.
David Hanny, Sebastian Schmidt, Shaily Gandhi, Michael Granitzer, Bernd Resch   +4 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Cohort profile: the National Congenital Anomaly Registration Dataset in England

BMJ Open
Purpose The National Congenital Anomaly and Rare Disease Registration Service (NCARDRS), part of National Disease Registration Service in National Health Service England, quality assures, curates and analyses individual data on the pregnancies, fetuses ...
Danielle Martin, Sarah Stevens, John Broggio, Chloe Johnson, Kate M Fleming, Ben Wreyford, Sylvia Stoianova, Gabriella Melis, Ewoma Obaro, Jennifer M. Broughan, Kay Randall, Nicholas Aldridge, Donna Gibbard   +12 more
doaj   +1 more source