Results 71 to 80 of about 2,413,906 (309)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Phase transformation kinetics model for metals

International Journal of Plasticity
We develop a new model for phase transformation kinetics in metals by generalizing the Levitas-Preston (LP) phase field model of martensite phase transformations (see Levitas and Preston (2002a,b); Levitas, Preston and Lee (2003)) to arbitrary pressure.
Daniel N. Blaschke, Abigail Hunter, Dean L. Preston   +2 more
openaire   +2 more sources

Kinetics of phase transformations in depletion-driven colloids

Physical Review E, 2004
We present results from a detailed numerical study of the kinetics of phase transformations in a model two-dimensional depletion-driven colloidal system. Transition from a single, dispersed phase to a two-phase coexistence of monomers and clusters is obtained as the depth of the interaction potential among the colloidal particles is changed. Increasing
Cerdà, Joan J., Sintes, Tomàs, Sorensen, C. M., Chakraborti, Anirban   +3 more
openaire   +3 more sources

New model for the overall transformation kinetics of bainite. Part 2: Validation [PDF]

, 2006
A new model for the overall kinetics of the bainite transformation has been validated experimentally. The new model, presented in the 1st part of this work, is based in the displacive mechanism for bainite transformation. Thus, the bainite transformation
García Mateo, Carlos, García Caballero, Francisca, Santofimia, Maria Jesús, Capdevila, Carlos, García de Andrés, Carlos, Francisca G. Caballero, Carlos Garc & iacute;a-Mateo, Santofimia, M. J., uacute;s & iacute;a Jes & Mar Santofimia, iacute;a de & Carlos Garc Andr & eacute;s, Carlos Capdevila   +10 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

TRANSFORMATION KINETICS FOR NUCLEATION ON RANDOM PLANES AND LINES

Image Analysis & Stereology, 2011
Birth and growth processes are known in materials science as nucleation and growth processes. In crystalline materials nucleation almost always takes place in an internal crystalline defect. These defects are classified according to their dimensionality: point, line or planar defects.
E. Villa, P. R. Rios
openaire   +5 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Kinetics of pressure-induced a-gt;w transformation in TI [PDF]

, 1982
The kinetics of the pressure-induced a-transformation in titanium is reported in the pressure range 5-9GPa. The occurance of this transformation under shock loading has been discussed using the observed pressure dependence of the ...
Mohan, Murali, Singh, AK, Divakar, C
core  

Stabilization and transformation kinetics of the metastable phases of liquid-quenched antimony

, 1979
Electron diffraction and differential thermal analysis studies have shown that the formation of metastable phases in antimony on liquid-quenching bythe "gun" technique is dependent on the rupture pressure of the "gun".
Akhtar, Dilshad, Vankar, V. D., Goel, T. C., Chopra, K. L.   +3 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source