Results 51 to 60 of about 3,292,740 (304)

Continuous Cooling Transformation Behaviour and Bainite Transformation Kinetics of 23CrNi3Mo Carburised Steel

Metals, 2020
In this study, the phase transformation behaviour of the carburised layer and the matrix of 23CrNi3Mo steel was comparatively investigated by constructing continuous cooling transformation (CCT) diagram, determining the volume fraction of retained ...
Wenjun Song, Min Lei, Mingpan Wan, Chaowen Huang   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

THE KINETICS OF AUSTENITE TRANSFORMATION IN THE RAIL STEEL GRADES M74 AND 75 ХГСМ DURING CONTINUOUS COOLING

Nauka ta progres transportu, 2009
The particularities of the shaping of microstructure of rail steels of marks М74 and 75ХГСМ under continuous cooling with different velocities from austenite interval of temperature are described; the temperature borders of the areas of phase ...
F. K. Tkachenko, S. O. Kuzmin, V. H. Yefremenko, V. H. Kazankov   +3 more
doaj  

Effects of Stress State and Microstructure on Deformation-Induced Transformation and Ageing in Medium-Manganese TRIP Steels

Metals
This study examines the mechanical response of medium-manganese TRIP steels under different stress states, focusing on deformation-induced austenite-to-martensite transformation and ageing phenomena. Two steels with distinctly different ferrite–austenite
Javier Carreno-Saavedra, Roumen H. Petrov, Patricia Verleysen   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of Heating Rate on the Kinetics of Martensitic Transformation of Ni-Ti-Hf alloys using Differential Scanning Calorimetry (DSC) [PDF]

Materials Research
The transformation martensite-austenite and Kinetics in Ni-Ti-Hf shape memory alloys (SMAs) were calculated for the first time. The Johnson- Mehl – Avrami- Komogorov (JMAK) equation was used to simulate the transformation Martensite- Austenite, which ...
Glauco R. de F. Brito, Walman B. de Castro, Roniere L. Soares   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Austenite Formation Kinetics of Dual-Phase Steels: Insights from a Mixed-Control Model Under Different Heating Conditions

Modelling
A semi-analytical mixed-control model based on the Non-Partitioned Local Equilibrium (NPLE) assumption was developed to simulate the austenite phase transformation kinetics during heating and isothermal processes. The model was validated by comparing the
Huifang Lan, Xiaoying Hui, Jiangbo Du, Shuai Tang, Linxiu Du   +4 more
doaj   +1 more source

Method to Evaluate the Kinetics of Bainite Transformation in Low-Temperature Nanobainitic Steel Using Thermal Dilatation Curve Analysis

Metals, 2017
The aim of this work was to develop a method to evaluate the kinetics of bainite transformation by theoretical deduction and thermal dilatation curve analysis. A Gleeble-3500 thermomechanical simulator and dilatometer (DIL805A) were employed to study the
Yaowen Xu, Guang Xu, Xinping Mao, Gang Zhao, Siqian Bao   +4 more
doaj   +1 more source