Results 41 to 50 of about 3,292,740 (304)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Transformation stasis phenomenon and overall transformation kinetics of low-carbon, Nb-bearing ferrous alloy

Journal of Materials Research and Technology, 2020
To illuminate the overall transformation kinetics of low-carbon, Nb-bearing ferrous Alloy (Nb ferrous alloy), a novel method was proposed to investigate the overall transformation behavior on the basis of bainitic transformation stasis theory.
J.H Zhao, C.H Jin, Y Lai, G Yuan, X.Q Wang, K.W Zhang   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Kinetics of the cercaria-schistosomulum transformation in vivo

Revista da Sociedade Brasileira de Medicina Tropical, 1985
Sitice most studies on the cercaria-schistosomulum transformation have been carried out in vitro, the authors used the inoculation ofcercariae into the peritoneal cavity of mice tofollow the steps involved in this progressive adaptation of cercarie to ...
A. L. Melo, L. H. Pereira
doaj   +3 more sources

Back-transformation processes in high-pressure minerals: implications for planetary collisions and diamond transportation from the deep Earth

Progress in Earth and Planetary Science, 2022
We conducted back-transformation experiments in ringwoodite, bridgmanite, and lingunite at 0.47–8.1 GPa and 310–920 °C by in situ X-ray observation method. Ringwoodite back-transformed to olivine by grain-boundary nucleation and growth mechanism.
Tomoaki Kubo, Ko Kamura, Masahiro Imamura, Yoshinori Tange, Yuji Higo, Masaaki Miyahara   +5 more
doaj   +1 more source

BAINITE : OVERALL TRANSFORMATION KINETICS

Le Journal de Physique Colloques, 1982
New experimental results on the overall transformation kinetics of the bainite reaction (in three different steels) are interpreted in terms of recent work on the transformation mechanism of bainite. The analysis is shown to be consistent with (a) a linear dependence of the activation energy for isothermal nucleation, on the transformation free energy ...
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The role of the austenite grain size in the martensitic transformation in low carbon steels

Materials & Design, 2019
There is sufficient experimental evidence to propose that the formation kinetics of athermal martensite directly depends on the austenite grain structure from which the martensite forms. Yet, this dependence is frequently ignored.
Carola Celada-Casero, Jilt Sietsma, Maria Jesus Santofimia   +2 more
doaj   +1 more source